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Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

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Updated: Jun 27, 2026

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Engineering Strategies for Plant-Derived Extracellular Vesicles: Modification, Drug Delivery Performance, and

Xiaoxiao Qiu1,2,3,4, Yilixiati Wusiman1,2,3,4, Nazhakaiti Yusufujiang1,2,3,4

  • 1Department of Pharmacology, College of Pharmacy, Xinjiang Medical University, Urumqi 830017, China.

Pharmaceutics
|June 26, 2026
PubMed
Summary

Plant-derived extracellular vesicles (PDEVs) offer a dual-function nanocarrier system. This review outlines engineering strategies and design principles for their use in precision nanomedicine, particularly for localized drug delivery.

Keywords:
drug deliveryengineered modificationgel compositesnanocarriersplant-derived extracellular vesiclessynergistic therapy

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Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
09:39

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

Area of Science:

  • Nanomedicine
  • Biotechnology
  • Materials Science

Background:

  • Plant-derived extracellular vesicles (PDEVs) are natural nanocarriers with beneficial properties like low immunogenicity and biocompatibility.
  • PDEVs possess inherent pharmacological activity, enabling dual roles as carriers and active agents.
  • Existing reviews often focus on specific diseases or engineering methods, lacking a comprehensive framework.

Purpose of the Study:

  • To establish a conceptual framework for engineering PDEVs for precision nanomedicine.
  • To integrate engineering strategies, carrier-performance synergy, and gel-composite design for PDEVs.
  • To explore the clinical potential of PDEVs, especially in localized drug delivery for dermatological conditions.

Main Methods:

  • Review of engineering strategies including targeted modification, stability enhancement, and drug loading optimization.
  • Analysis of the carrier-performance-synergy paradigm linking PDEV composition to therapeutic outcomes.
  • Investigation of gel-composite design principles for controllable local drug delivery platforms.

Main Results:

  • PDEVs can be engineered to overcome limitations in targeting, stability, and loading efficiency.
  • The intrinsic bioactivity of PDEVs synergizes with delivered drugs, enhancing therapeutic outcomes.
  • PDEV gel composites show promise for localized drug delivery, particularly for skin conditions.

Conclusions:

  • A theoretical framework for rational PDEV design and clinical translation is presented.
  • PDEVs represent a promising platform for innovative precision nanomedicine.
  • Future research should focus on synthetic biology, multi-omics, and clinical translation of PDEVs.