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Inflammatory Bowel Disease IV: Pharmacological Management

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Updated: Jun 27, 2026

Facilitating Drug Discovery: An Automated High-content Inflammation Assay in Zebrafish
07:50

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Published on: July 16, 2012

Bioactive Anti-Inflammatory Compounds and Therapeutic Strategies for Promoting Resolution.

Dipa K Israni1, Mansi Shah1, Heena Chauhan1

  • 1Department of Pharmacology, LJ Institute of Pharmacy, LJ University, Ahmedabad 382210, Gujarat, India.

Pharmaceutics
|June 26, 2026
PubMed
Summary
This summary is machine-generated.

Natural compounds offer safer anti-inflammatory benefits by modulating immune responses and targeting chronic inflammation pathways. This review highlights plant-derived molecules and novel strategies for improved therapeutic outcomes.

Keywords:
bioactive compoundsinflammation resolutionnanoformulationoxidative stresspersonalized medicinepro-resolving mediators

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Area of Science:

  • * Integrative immunology and natural product chemistry.
  • * Focus on chronic inflammation and immune homeostasis.

Background:

  • * Chronic inflammation underlies numerous diseases, with conventional drugs having limitations.
  • * Natural bioactive molecules present safer alternatives for managing inflammation.
  • * Phytochemicals modulate key inflammatory and oxidative stress pathways.

Purpose of the Study:

  • * To review the therapeutic potential of natural plant products for chronic inflammation.
  • * To explore novel anti-inflammatory strategies beyond suppression.
  • * To highlight advancements in targeted delivery and personalized medicine.

Main Methods:

  • * Comprehensive review of preclinical and clinical studies on natural anti-inflammatory agents.
  • * Analysis of signaling pathways (NF-κB, MAPK, JAK/STAT) and mechanisms (Nrf2/HO-1).
  • * Examination of emerging therapeutic approaches like nanoformulations and microbiota modulation.

Main Results:

  • * Natural products like quercetin, resveratrol, and lycopene demonstrate significant anti-inflammatory effects.
  • * Novel strategies include specialized pro-resolving lipid mediators and microbiota-targeted therapies.
  • * Personalized medicine approaches using multi-omics enhance treatment efficacy.

Conclusions:

  • * Bioactive compounds from natural sources synergize with advanced techniques to combat chronic inflammation.
  • * Resolution-based strategies and targeted delivery offer promising therapeutic avenues.
  • * Restoring immune homeostasis is achievable through integrated natural product and modern therapeutic approaches.