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Updated: Jun 27, 2026

Characterization of Immune Cell-derived Extracellular Vesicles and Studying Functional Impact on Cell Environment
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Characterization of Immune Cell-derived Extracellular Vesicles and Studying Functional Impact on Cell Environment

Published on: June 2, 2020

Cell-Specific Extracellular Vesicles Targeting Strategies for Immune Modulation in Inflammatory Diseases.

Junha Lee1, Suan Kwon2, Yoosoo Yang1,3

  • 1Department of MetaBioHealth, School of Medicine, Sungkyunkwan University, Suwon 16419, Republic of Korea.

Pharmaceutics
|June 26, 2026
PubMed
Summary
This summary is machine-generated.

Extracellular vesicles (EVs) engineered with targeting ligands offer improved immune modulation for inflammatory diseases. Surface modification enhances selective delivery to immune cells, optimizing therapeutic outcomes.

Keywords:
cell targetingchemical conjugationextracellular vesiclesinflammatory diseasessurface engineering

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Published on: September 23, 2021

Area of Science:

  • Nanomedicine
  • Immunology
  • Biotechnology

Background:

  • Extracellular vesicles (EVs) are natural nanocarriers with therapeutic potential for immune modulation.
  • Clinical translation of EV-based therapies is limited by poor cell-specific targeting and biodistribution in inflammatory diseases.

Purpose of the Study:

  • To review advances in cell-specific EV targeting strategies for immune modulation in inflammatory diseases.
  • To highlight EV surface engineering approaches for enhanced therapeutic efficacy and reduced off-target effects.

Main Methods:

  • Comprehensive review of recent literature on EV targeting strategies.
  • Focus on active targeting through EV surface engineering with various ligands (antibodies, peptides, aptamers, glycans, membrane proteins).

Main Results:

  • Engineered EVs demonstrate enhanced selective interactions with specific immune cell subsets like macrophages and T cells.
  • Targeting strategies can reprogram immune phenotypes and suppress pathological inflammation.

Conclusions:

  • Rational design of EV-cell interactions via surface engineering is crucial for developing effective immunomodulatory therapeutics.
  • Cell-specific EV targeting holds promise for restoring immune homeostasis in inflammatory conditions.