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Related Experiment Video

Updated: Jun 27, 2026

Growth of Human and Sheep Corneal Endothelial Cell Layers on Biomaterial Membranes
05:20

Growth of Human and Sheep Corneal Endothelial Cell Layers on Biomaterial Membranes

Published on: February 6, 2020

Biomaterial-Assisted Strategies in Corneal Endothelial Cell Therapy: Toward a Platform-Based Approach.

Yura Choi1, Mi-Young Jung1, Choul Yong Park1

  • 1Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Republic of Korea.

Pharmaceutics
|June 26, 2026
PubMed
Summary

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Biomaterial-assisted corneal endothelial cell therapy (CECT) offers a promising solution for corneal blindness by improving cell retention and adhesion. This regenerative approach aims to overcome limitations of current cell injection therapies for better patient outcomes.

Area of Science:

  • Ophthalmology
  • Regenerative Medicine
  • Biomaterials Science

Background:

  • Corneal endothelial dysfunction causes significant vision loss globally.
  • Limited regenerative capacity of corneal endothelial cells (CECs) and donor tissue shortage necessitate alternative treatments.
  • Current corneal endothelial cell therapy (CECT) faces challenges like poor cell retention and distribution.

Purpose of the Study:

  • To review next-generation CECT strategies utilizing biomaterials.
  • To analyze methods for enhancing cell retention, localization, and adhesion post-injection.
  • To explore patent trends, regulatory landscapes, and market dynamics in CECT.

Main Methods:

  • Review of recent advancements in biomaterials and regenerative engineering for CECT.
Keywords:
ECM-mimicking nanofibersclick chemistry hydrogelcontrolled cell deliverycorneal endothelial cell therapy (CECT)ocular drug delivery

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Corneal Donor Tissue Preparation for Endothelial Keratoplasty
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Last Updated: Jun 27, 2026

Growth of Human and Sheep Corneal Endothelial Cell Layers on Biomaterial Membranes
05:20

Growth of Human and Sheep Corneal Endothelial Cell Layers on Biomaterial Membranes

Published on: February 6, 2020

Combination of Microstereolithography and Electrospinning to Produce Membranes Equipped with Niches for Corneal Regeneration
11:42

Combination of Microstereolithography and Electrospinning to Produce Membranes Equipped with Niches for Corneal Regeneration

Published on: September 12, 2014

Corneal Donor Tissue Preparation for Endothelial Keratoplasty
08:37

Corneal Donor Tissue Preparation for Endothelial Keratoplasty

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  • Analysis of studies investigating biomaterial-assisted cell delivery mechanisms.
  • Examination of global patent filings, regulatory guidelines, and market data.

    • Main Results:

    • Biomaterial-assisted strategies show potential to improve cell retention, spatial localization, and long-term adhesion.
    • Emerging approaches aim to reduce variability in cell distribution and retention compared to conventional CECT.
    • Despite promising preclinical data, translational feasibility and long-term efficacy require further investigation.

    Conclusions:

    • Biomaterial-assisted CECT represents a next-generation regenerative strategy for corneal blindness.
    • Overcoming key challenges is crucial for successful clinical translation of these advanced therapies.
    • These approaches may lead to more scalable, minimally invasive treatments with improved engraftment efficiency.