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Published on: May 2, 2025
Thymoquinone-Loaded Electrospun Fibrous Mats as Advanced Wound Dressing Materials
Magdalena Paczkowska-Walendowska1,2, Elwira Sieniawska3, Zbigniew Krasiński4
1Department of Pharmacognosy and Biomaterials, Poznan University of Medical Sciences, Rokietnicka 3, 60-806 Poznan, Poland.
Pharmaceutics
|June 26, 2026
Summary
Electrospun nanofibers enhance thymoquinone (TQ) delivery for wound healing. PVP/PCL nanofibers show sustained release and superior wound closure, indicating promise for advanced wound dressings.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Pharmacology
Background:
- Thymoquinone (TQ), from Nigella sativa, has antioxidant and anti-inflammatory benefits.
- Poor solubility and stability limit TQ's clinical use.
- Novel delivery systems are needed for effective TQ application.
Purpose of the Study:
- To develop electrospun nanofiber wound dressings for controlled TQ delivery.
- To evaluate the impact of different polymer matrices on TQ release and biological activity.
- To identify optimal nanofiber formulations for wound healing.
Main Methods:
- Three electrospun nanofiber systems (PVP, PVP/HPβCD, PVP/PCL) were fabricated for TQ delivery.
- Physicochemical properties (fiber diameter, TQ dispersion) were analyzed (SEM, XRPD, FTIR).
- Drug release kinetics, antioxidant, anti-inflammatory, mucoadhesion, and wound healing efficacy were assessed.
Main Results:
- All nanofibers showed uniform structures with dispersed TQ.
- PVP/HPβCD nanofibers offered fast release and improved solubility-driven bioactivity.
- PVP/PCL nanofibers exhibited sustained release, high mucoadhesion, and 90% wound closure in 24h.
- HPβCD enhanced TQ stability; PCA identified drug availability and sustained release/bioadhesion as key performance factors.
Conclusions:
- Polymer composition critically modulates TQ delivery and biological outcomes.
- PVP/PCL nanofibers demonstrate significant potential for wound dressing applications.
- Sustained release and bioadhesion are crucial for enhanced wound regeneration via TQ delivery.
