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Published on: April 3, 2018

Exploring the Isoprenoid Biosynthesis Pathway's Role in Oncogenic Viruses

Louise N Blaha1,2, Jeffrey D Neighbors1,2, Richa Sandeep3

  • 1Penn State Cancer Institute, Hershey, PA 17033, USA.

Viruses
|June 26, 2026
PubMed

Insights

Oncogenic viruses drive over 10% of cancers by reprogramming cellular metabolism, particularly the isoprenoid biosynthesis pathway (IBP). This study highlights the IBP

Area of Science:

  • Oncology
  • Virology
  • Metabolic Pathways

Background:

  • Oncogenic viruses cause over 10% of human cancers.
  • These viruses often reprogram host cellular metabolism for survival and proliferation.
  • Lipogenic pathways, including the isoprenoid biosynthesis pathway (IBP), are frequently targeted.

Purpose of the Study:

  • To comprehensively discuss the seven known oncogenic viruses and their dependence on the IBP for tumorigenesis.
  • To highlight a neglected area in oncogenic research.
  • To explore inhibitors of the IBP as potential novel cancer therapies.

Main Methods:

  • Comprehensive literature review and discussion.
  • Analysis of the role of the isoprenoid biosynthesis pathway (IBP) in virus-associated cancers.
  • Exploration of existing and potential therapeutic strategies targeting the IBP.

Main Results:

  • Oncogenic viruses rely on the isoprenoid biosynthesis pathway (IBP) for promoting tumor development.
  • Dysregulation of the IBP is a common mechanism in virus-induced carcinogenesis.
  • Inhibitors of the IBP represent a promising therapeutic avenue.

Conclusions:

  • The isoprenoid biosynthesis pathway (IBP) is a critical factor in oncogenesis driven by viruses.
  • Targeting the IBP offers a novel strategy for treating virus-associated cancers.
  • Further research into IBP inhibitors is warranted for cancer therapy development.
Keywords:
HMGCRcholesterolfarnesyl pyrophosphategeranylgeranyl pyrophosphateisoprenoidsmevalonatemicroRNAoncovirusprenylationstatin

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