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Updated: Jun 27, 2026
![Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-(phosphinetriyl)tripiperidine]}palladium Under Mild Reaction Conditions](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F51444.jpg&w=3840&q=50)
Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-(phosphinetriyl)tripiperidine]}palladium Under Mild Reaction Conditions
Published on: March 20, 2014
Ni-Catalyzed Cross-Electrophile Coupling of Acyl Phosphate Ester and Alkyl Bromide to Form Aryl Ketone under Room
1Department of Chemistry, Nanchang University, Nanchang, 330031, P. R. China.
Abstract:
The synthesis of aryl ketones from aryl carboxylic acid derivatives is a fundamental transformation in organic synthesis. Herein, we report a nickel-catalyzed cross-electrophile coupling of acyl phosphate esters with alkyl bromides for the efficient construction of aryl ketones. The reaction proceeds under mild conditions and exhibits broad tolerance to various functional groups. A wide range of acyl phosphate esters and alkyl bromides participate efficiently in this coupling. The successful late-stage functionalization of bioactive molecules further highlights the synthetic utility of this strategy. Mechanistic studies support the involvement of an alkyl radical pathway.
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