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Related Concept Videos

REM Sleep Behavior Disorder01:15

REM Sleep Behavior Disorder

REM Sleep Behavior Disorder (RBD) is a sleep disorder characterized by the absence of muscle paralysis that normally occurs during the REM phase of sleep. This absence allows individuals to physically act out their dreams, which are often vivid and disturbing. Common behaviors exhibited during episodes include kicking, punching, and yelling. These actions can be dangerous, potentially leading to injuries for the person with RBD or their bed partner.
RBD is significantly associated with...
Insufficient Sleep and Sleep Deprivation01:13

Insufficient Sleep and Sleep Deprivation

Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
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Substance Use Disorders Affecting Sleep

Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
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Management of Insomnia

The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...
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Anxiolytic Drugs: Overview

Anxiolytic drugs are vital in managing anxiety disorders by effectively alleviating symptoms such as excessive fear, tachycardia, and tremors. There are several classes of anxiolytic medications, each with unique mechanisms of action and potential side effects.
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Related Experiment Video

Updated: Jun 27, 2026

A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice
06:23

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Published on: September 22, 2020

UBOX5 Modulates the Cognitive Dysfunction by Degrading HSP70 Protein in Sleep-Deprived Mice.

Guoshao Zhu1, Changsheng Su1, Zhenming Kang1

  • 1Department of Anesthesiology, Quanzhou First Hospital Affiliated to Fujian Medical University, Quanzhou, Fujian 362000, China.

ACS Chemical Neuroscience
|June 26, 2026
PubMed
Summary

Sleep deprivation impairs memory by reducing hippocampal Heat Shock Protein 70 (HSP70). The E3 ligase UBOX5 targets HSP70 for degradation, worsening cognitive decline and neuroinflammation.

Keywords:
HSP70UBOX5cognitive impairmentsleep deprivationubiquitination

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Published on: February 21, 2021

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Sleep Science

Background:

  • Sleep deprivation is a global health issue linked to cognitive decline.
  • Heat shock protein 70 (HSP70) is crucial for neuronal survival but its regulation during sleep loss is unknown.

Purpose of the Study:

  • To investigate the regulatory mechanism of HSP70 during sleep deprivation.
  • To explore the role of E3 ligase UBOX5 in HSP70 regulation and its impact on cognitive function.

Main Methods:

  • Established a murine sleep deprivation model.
  • Assessed cognitive performance using Y-maze and novel object recognition tests.
  • Utilized Western blotting, qRT-PCR, CHX chase, and coimmunoprecipitation to study UBOX5-HSP70 interaction.

Main Results:

  • Sleep deprivation decreased hippocampal HSP70 and impaired memory.
  • UBOX5 expression increased with sleep deprivation and accelerated HSP70 degradation.
  • UBOX5 knockout mice showed reduced cognitive impairment and neuroinflammation after sleep deprivation.

Conclusions:

  • UBOX5 destabilizes HSP70 through ubiquitination, contributing to sleep deprivation-induced cognitive deficits and neuroinflammation.
  • The UBOX5/HSP70 pathway is a novel link between sleep loss and neuronal injury.
  • Targeting the UBOX5/HSP70 axis may offer therapeutic benefits for sleep deprivation-related neurological damage.