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Determining the Association Between Clear Cell Acanthoma and Psoriasis: A Retrospective Case-Control Study
Romina Garakani1,2, Zane Sejdiu1,2, Claire Rose Kissinger3
1Drexel University College of Medicine, Philadelphia, PA.
The American Journal of Dermatopathology
|June 26, 2026
Summary
Clear cell acanthoma, a benign skin condition, does not appear to be linked with psoriasis. This study found no significant association between clear cell acanthoma and psoriasis.
Area of Science:
- Dermatology
- Epidemiology
Background:
- Clear cell acanthoma shares clinical similarities with psoriasis.
- Psoriasis is associated with cardiovascular comorbidities.
Purpose of the Study:
- To investigate the potential association between clear cell acanthoma and psoriasis.
- To compare the prevalence of psoriasis and cardiovascular comorbidities in patients with clear cell acanthoma versus seborrheic keratosis.
Main Methods:
- Retrospective cohort study.
- Comparison of patient data for clear cell acanthoma and seborrheic keratosis.
- Analysis of psoriasis and cardiovascular comorbidity presence.
Main Results:
- No significant relationship was found between clear cell acanthoma and psoriasis.
- Prevalence of psoriasis did not differ significantly between the two groups.
Conclusions:
- Clear cell acanthoma is not significantly associated with psoriasis.
- Further research may be needed to explore other potential associations or differentiating factors.
