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Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...

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Gray zone possibility in repeat Bethesda III cytology: a retrospective cohort study of malignancy and multifocality in thyroid nodules.

Annals of surgical treatment and research·2026
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Related Experiment Video

Updated: Jun 27, 2026

A 3D Organotypic Melanoma Spheroid Skin Model
08:49

A 3D Organotypic Melanoma Spheroid Skin Model

Published on: May 18, 2018

Melanoma Colonizing Basal Cell Carcinoma: A Rarely Described Entity.

Ferhat Özden1, İbrahim Serdar Coşkun2, İhsan Kasapgil3

  • 1Department of Pathology, International School of Medicine, Istanbul Medipol University, Istanbul, Turkey.

The American Journal of Dermatopathology
|June 26, 2026
PubMed
Summary

Collision tumors of basal cell carcinoma (BCC) and melanoma are rare. Accurate diagnosis requires detailed histopathology and immunohistochemistry, as melanoma dictates prognosis.

Keywords:
Basal cell carcinomaCollision tumorColonizationImmunohistochemistryMelanomaPRAMEp16 loss

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Patient Derived Cell Culture and Isolation of CD133+ Putative Cancer Stem Cells from Melanoma
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Patient Derived Cell Culture and Isolation of CD133+ Putative Cancer Stem Cells from Melanoma

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Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
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Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

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Last Updated: Jun 27, 2026

A 3D Organotypic Melanoma Spheroid Skin Model
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Patient Derived Cell Culture and Isolation of CD133+ Putative Cancer Stem Cells from Melanoma
12:16

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Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
06:09

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

Published on: June 7, 2019

Area of Science:

  • Dermatopathology
  • Oncology

Background:

  • Collision tumors combining basal cell carcinoma (BCC) and melanoma are exceptionally rare.
  • Distinguishing these tumors from melanoma colonization presents diagnostic challenges.

Purpose of the Study:

  • To present a case of a rare BCC-melanoma collision/colonization tumor.
  • To highlight the diagnostic complexities and prognostic implications.

Main Methods:

  • Histopathological examination of a lower lip lesion.
  • Immunohistochemical analysis to confirm biphasic nature (melanocytic and epithelial components).
  • Assessment of melanoma Breslow thickness, ulceration, and invasion.

Main Results:

  • A 68-year-old man presented with an ulcerated lesion initially suspected as BCC.
  • Histopathology revealed BCC with melanoma colonization (7.5 mm Breslow thickness, ulceration, perineural invasion).
  • Immunohistochemistry confirmed distinct melanocytic (S100+, Melan-A+, SOX10+, PRAME+, p16-) and epithelial (p40+, Bcl-2+) components.

Conclusions:

  • This case underscores the diagnostic difficulty of BCC-melanoma collision/colonization tumors.
  • Prognosis is primarily determined by the melanoma component.
  • Meticulous histopathologic evaluation and immunohistochemistry are crucial for patient management.