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Updated: Jun 27, 2026

A Guide to Production, Crystallization, and Structure Determination of Human IKK1/α
Published on: November 2, 2018
[Research progress on the regulatory mechanism of ubiquitination on canonical NF-κB signaling pathway]
Ying-Ying Jiang1,2, Xiang-Jie Chen1, Fang Gong1,2
1Clinical Laboratory, Central Hospital Affiliated to Jiangnan University, Wuxi 214002, China.
Abstract:
NF-κB signaling pathway is a key regulatory pathway of inflammation and immune response, and its activation can promote the production of inflammatory factors and inhibit apoptosis. In the canonical NF-κB signaling pathway, ubiquitin modification plays an important regulatory role, in which the ubiquitin chain formed by lysine residues 48, 63 (K48, K63) and methionine 1 (Met1) is more closely related to the NF-κB pathway. This paper aims to summarize the role of K48, K63 and Met1-linked ubiquitination in the canonical NF-κB signaling pathway, which is of great significance to further understand the mechanism of these ubiquitin-linked types and reveal their molecular regulation mechanism on NF-κB pathway, and provide new targets and strategies for the treatment of inflammatory and immune-related diseases.
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