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Updated: Jun 27, 2026

In Vitro Modeling of Fat Deposition in Metabolic Dysfunction-Associated Steatotic Liver Disease
Published on: July 19, 2024
[Research progress on the role of the microbiota-gut-liver axis immune pathway in metabolic dysfunction-associated
Shun-Ling Yuan1,2, Yuan-Qi Huang1, Chuang-Tao Li1
1Provincial University Key Laboratory of Sport and Health Science, School of Physical Education and Sport Sciences, Fujian Normal University, Fuzhou 350117, China.
Abstract:
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a widely prevalent chronic liver disease that presents significant challenges to public health and medical care worldwide, yet its underlying mechanisms remain incompletely understood. The gut microbiome plays a crucial role in MASLD. Liver inflammation is a key factor in the onset and progression of this disease, and the gut microbiota significantly influences the liver's immune system and inflammatory responses. This article aims to review how both pro-inflammatory and anti-inflammatory gut microbes regulate liver inflammation by activating liver immunity and enhancing liver immune protection, respectively, through the microbiota-gut-liver axis. This review seeks to provide valuable insights for the improvement and treatment of MASLD.
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