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  3. Rope-skipping For Blood Plasma Separation In Point-of-care Testing.
  1. Home
  3. Rope-skipping For Blood Plasma Separation In Point-of-care Testing.

Related Experiment Video

A Practical and Novel Method to Extract Genomic DNA from Blood Collection Kits for Plasma Protein Preservation
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Published on: May 18, 2013

Rope-skipping for blood plasma separation in point-of-care testing.

Ruoyu Yuan1, Xianchang Wu2, Tonghuan Zhan2

  • 1Department of Clinical Laboratory, Affiliated Hospital of Nantong University, Nantong 226001, China. wangxudong88@hotmail.com.

The Analyst
|June 26, 2026

View abstract on PubMed

Summary
This summary is machine-generated.

A novel rope-skipping microfluidic centrifugation (RSMC) method offers efficient plasma separation for point-of-care testing (POCT). This simple, low-cost technique achieves high purity and yield, making it ideal for resource-limited settings.

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Area of Science:

  • Biomedical Engineering
  • Clinical Diagnostics
  • Microfluidics

Background:

  • Plasma separation is crucial for biomarker detection in clinical diagnosis.
  • Conventional centrifugation is impractical for point-of-care testing (POCT) due to equipment and time constraints.
  • Red blood cell interference can affect biomedical detection accuracy.

Purpose of the Study:

  • To develop a simple, cost-effective plasma separation method for POCT in resource-limited settings.
  • To introduce the rope-skipping microfluidic centrifugation (RSMC) technique.
  • To evaluate the performance of RSMC for blood sample pre-processing.

Main Methods:

  • A blood sample tube was secured to a rope-skipping device and manually rotated at approximately 200 rpm.
  • Centrifugal force was utilized for efficient plasma separation without electricity.
  • The RSMC method was tested for plasma yield, purity, and biomarker recovery.

    • Main Results:

    • Achieved 67.3% plasma yield with 99.99% purity within 5 minutes.
    • Demonstrated high blood glucose recovery rate (98.3%), comparable to standard centrifuges.
    • Successfully pre-processed large volumes (mL) of whole blood samples.

    Conclusions:

    • RSMC is a simple, cost-effective, and easy-to-operate method for plasma separation.
    • The technique is highly suitable for POCT applications, especially in resource-limited environments.
    • RSMC overcomes limitations of conventional methods and manual alternatives for rapid diagnostics.