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Updated: Jun 27, 2026

Tick Microbiome Characterization by Next-Generation 16S rRNA Amplicon Sequencing
07:21

Tick Microbiome Characterization by Next-Generation 16S rRNA Amplicon Sequencing

Published on: August 25, 2018

Research progress on emerging and important Tick-Borne pathogens

Gang Duan1, Linghan Kong2, Sicheng Duan3

  • 1Chongqing Key Laboratory of Highly Pathogenic Microbes, Chongqing Research Center for Disease Prevention and Public Health, Chongqing Center for Disease Control and Prevention, Chongqing Academy of Preventive Medicine, Chongqing, China.

Frontiers in Microbiology
|June 26, 2026
PubMed

Insights

This review covers tick-borne pathogens like Borrelia and viruses, detailing their genomic diversity, transmission, and immune evasion. It also discusses advanced detection methods and highlights challenges in vaccine development and surveillance for tick-borne diseases.

Area of Science:

  • Veterinary Entomology
  • Infectious Diseases
  • Public Health

Background:

  • Ticks are significant vectors of pathogens, posing global public health risks.
  • Tick-borne diseases include Lyme disease, babesiosis, and viral infections like SFTSV and TBEV.

Purpose of the Study:

  • To review research on main and emerging tick-borne pathogens.
  • To focus on genomic diversity, pathogenicity, transmission, immune escape, and co-infections.
  • To summarize new detection technologies and identify research limitations and future directions.

Main Methods:

  • Literature review of tick-borne pathogens and associated research.
  • Analysis of genomic diversity, pathogenicity, and transmission mechanisms.
  • Evaluation of novel detection technologies such as CRISPR, mNGS, and microfluidics.

Main Results:

  • Detailed overview of key tick-borne pathogens (e.g., Borrelia, Rickettsia, Babesia, SFTSV, TBEV, ALSV).
  • Summary of advancements in understanding pathogen characteristics and host-pathogen interactions.
  • Assessment of emerging diagnostic tools for tick-borne disease detection.

Conclusions:

  • Significant progress in understanding tick-borne pathogens, but challenges remain.
  • Vaccine development and surveillance systems require enhancement.
  • Future research should focus on addressing current limitations for effective disease control.
Keywords:
AnaplasmaBabesiaBorreliaRickettsiaSFTSVTBEVTick-borne diseasesemerging pathogens

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