Related Experiment Video
Updated: Jun 27, 2026
A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing (Neo)adjuvant Therapies
Published on: July 28, 2020
Multidisciplinary team care and outcomes in FNCLCC grade 3 soft tissue sarcoma: a propensity score-matched and
Zhangfu Li1, Xinyu Li1, Baicheng Yang1
1Department of Orthopaedics, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Background:
Multidisciplinary team (MDT) care is widely advocated for soft tissue sarcoma (STS), yet real-world evidence in high-grade disease remains limited and subject to confounding. We investigated whether pre-treatment MDT care was associated with improved outcomes in FNCLCC grade 3 STS.
Methods:
This retrospective cohort study included consecutive adults with pathologically confirmed FNCLCC grade 3 STS treated at the Department of Orthopaedics, Cancer Hospital, Chinese Academy of Medical Sciences (2010-2022). MDT care was defined as formal discussion after pathological diagnosis and before definitive treatment. Primary endpoints were 3-year local recurrence and distant metastasis from diagnosis (administrative censoring at 36 months). Propensity scores were estimated using logistic regression; confounding was addressed using 1:1 propensity score matching (PSM) and stabilized inverse probability of treatment weighting (IPTW). Odds ratios (ORs) and Kaplan-Meier analyses were applied.
Results:
Among 338 patients (MDT, n=88; non-MDT, n=250), MDT care was associated with lower 3-year local recurrence (6.8% vs 21.2%; unadjusted OR = 0.272, P = 0.002), with consistent results after PSM (paired OR = 0.259, P = 0.021) and IPTW (OR = 0.296, P = 0.008). By contrast, 3-year distant metastasis did not differ significantly between groups in unadjusted, matched, or weighted analyses (weighted OR = 0.846, 95% CI 0.418-1.714; P = 0.643), although the confidence interval did not exclude a potentially moderate clinically meaningful benefit.
Conclusions:
In FNCLCC grade 3 STS, pre-treatment MDT care was associated with improved 3-year local control but not with a significant reduction in 3-year distant metastasis.
