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Sustained attention in dementia with Lewy bodies: a task-based fMRI study
Davide Braghittoni1, Greta Venturi1, Lucia Guidi1
1IRCCS Istituto delle Scienze Neurologiche di Bologna, Functional and Molecular Neuroimaging Unit, Bologna, Italy.
Dementia with Lewy Bodies (DLB) patients show impaired sustained attention and reduced brain activity in key attention networks. This finding highlights distinct neural patterns linked to attention deficits in DLB, guiding future cognitive treatments.
Area of Science:
- Neuroscience
- Cognitive Neurology
Background:
- Dementia with Lewy Bodies (DLB) is characterized by attentional deficits.
- Sustained attention is vital for higher cognitive functions.
Purpose of the Study:
- Investigate brain connectivity patterns during a sustained attention task in DLB patients versus healthy controls (HC).
- Identify neural correlates of attention deficits in DLB.
Main Methods:
- 30 DLB patients and 25 HC underwent neuropsychological assessment and 3T MRI.
- Task-based functional MRI (fMRI) utilized an auditory Psychomotor Vigilance Task (PVT).
Main Results:
- DLB patients exhibited poorer sustained attention (PVT lapses, slower responses) and visuospatial deficits.
- DLB group showed significantly lower activation in precuneus, intracalcarine cortex, angular gyrus, and cuneus during the PVT.
Conclusions:
- DLB patients display a distinct pattern of brain activity associated with attention impairment.
- Findings support the development of targeted cognitive stimulation therapies for DLB.
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