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Published on: March 10, 2015
Development and frontier trends of research on the gut microbiota and cholangiocarcinoma
Xusheng Zhang1,2, Hongkun Yin2, Di Liu1,2
1General Hospital of Ningxia Medical University, Yinchuan, 750004, China.
Background:
Although research on the gut microbiota and cholangiocarcinoma has developed rapidly in recent years, and the gut microbiota plays an important role in cholangiocarcinoma, there is currently a lack of comprehensive and objective understanding of the latest progress and future research directions in this field. This study comprehensively evaluated and visually analyzed this research area based on bibliometric methods.
Methods:
This analysis used tools such as the "Bibliometrix" R package, VOSviewer, CiteSpace, and Microsoft Office Excel (2019 version) to comprehensively conduct a bibliometric analysis of scientific research outputs related to the gut microbiota and cholangiocarcinoma. The data analyzed were all sourced from the Web of Science Core Collection (2009-2025).
Results:
A total of 124 research achievements published from 2009 to 2025 were included. Eight hundred and ninety-six researchers from 278 institutions in 37 countries/regions participated in the research on the gut microbiota and cholangiocarcinoma. The number of global publications has steadily increased, reaching a peak in 2024. China had the most publications and citations, followed by Italy and the United States. The University of Oslo, Khon Kaen University, and Università degli Studi di Palermo were the main institutions in this research area and made important contributions. Cancers, International Journal of Microorganisms, and Microorganisms were the most relevant journals in this research area. DI CARLO P, GIAMMANCO A, and SERRA N were the most relevant authors in this research area and made important contributions. The latest frontier research direction focuses on "metabolism", aiming to further explore the pathogenesis of cholangiocarcinoma through the gut microbiota and to find new therapeutic approaches.
Conclusion:
This study comprehensively summarized the development of research on the gut microbiota and cholangiocarcinoma from 2009 to 2025. The research results revealed the latest research frontiers and hotspots in this field and provided valuable insights for future research. However, it should be noted that although WoSCC is a widely recognized and authoritative database, it may have limitations in terms of regional bias, language coverage, and metadata accuracy, which may affect the comprehensiveness of our analysis.
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