Helium Plasma Radiofrequency for Aesthetic Subdermal Treatment: A Systematic Review and Meta-Analysis

Area of Science:

• Aesthetic Medicine
• Dermatology
• Plastic Surgery

Background:

• Helium plasma radiofrequency (RF) technology is a minimally invasive treatment for skin laxity.
• Its use is expanding, but the existing literature is varied.
• A comprehensive evaluation of its safety and efficacy is needed.

Purpose of the Study:

• To systematically review and meta-analyze the safety and performance of helium plasma RF for aesthetic subdermal applications.
• To provide pooled estimates for key outcomes like patient satisfaction and aesthetic improvement.

Main Methods:

• Systematic search of literature from device clearance to May 2025, following PRISMA guidelines.
• Inclusion of RCTs, prospective cohorts, retrospective reviews, and case series (≥10 patients).
• Meta-analyses for safety (complication rates) and performance (satisfaction, GAIS, photographic scores).

Main Results:

• 34 studies (3508 patients) were included.
• Pooled complication rates were low: 5% (RF-only), 8% (RF + liposuction), 15% (combination procedures).
• Pooled patient satisfaction was high at 92%, with longer follow-up correlating to higher satisfaction.

Conclusions:

• Helium plasma RF demonstrates a favorable safety profile for subdermal aesthetic applications.
• The technology is associated with high patient satisfaction and significant aesthetic improvement.
• This systematic review supports its efficacy as a standalone or adjunctive treatment.