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Related Experiment Videos

Guillain-Barré Syndrome Emerging From Syringomyelia Management: A Case Report.

Abbigail Niewchas1, Brandon Baccari2, Christopher Stewart1

  • 1College of Osteopathic Medicine, Kansas City University, Joplin, Missouri, USA, kcumb.edu.

Case Reports in Medicine
|June 26, 2026
PubMed
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Guillain-Barré syndrome coexisting with a spinal cord syrinx is rare. A cervical syrinx can mask GBS symptoms, delaying critical treatment and complicating patient outcomes.

Area of Science:

  • Neurology
  • Neurosurgery
  • Immunology

Background:

  • The coexistence of Guillain-Barré syndrome (GBS) and spinal cord syrinx is exceptionally rare.
  • This case involves a 57-year-old female with progressive neurological deficits.

Purpose of the Study:

  • To report a rare case of concurrent Guillain-Barré syndrome and cervical spinal cord syrinx.
  • To highlight diagnostic challenges and emphasize the importance of a broad differential diagnosis in complex neurological presentations.

Main Methods:

  • Case report detailing clinical presentation, diagnostic imaging (MRI), and electrophysiological studies (nerve conduction studies).
  • Review of patient's progression and treatment response.

Main Results:

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  • Cervical MRI revealed a syrinx from C2 to C7, initially leading to a diagnosis of syringomyelia.
  • Subsequent nerve conduction studies confirmed a sensorimotor demyelinating polyneuropathy, diagnosing Guillain-Barré syndrome.
  • The patient experienced respiratory failure, requiring mechanical ventilation and treatment with intravenous immunoglobulin, with transient stabilization but progressive decline.

    • Conclusions:

    • A cervical syrinx can obscure the presentation of Guillain-Barré syndrome, potentially delaying diagnosis and treatment.
    • Maintaining a broad differential diagnosis is crucial for patients with atypical or overlapping neurological findings.