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Related Experiment Video

Updated: Jun 27, 2026

High-density Electroencephalographic Acquisition in a Rodent Model Using Low-cost and Open-source Resources
12:39

High-density Electroencephalographic Acquisition in a Rodent Model Using Low-cost and Open-source Resources

Published on: November 26, 2016

Simplified method for EEG recordings in mice.

Bende Zou1, Xinmin Simon Xie1, Ludmila Gerashchenko2

  • 1AfaSci Research Laboratories, Redwood City, CA, United States.

Methodsx
|June 26, 2026
PubMed
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This study introduces a novel, minimally invasive method for implanting electroencephalogram (EEG) electrodes in mice using thin needle electrodes. This rapid technique simplifies surgical procedures, reducing implantation time and improving animal welfare.

Area of Science:

  • Neuroscience
  • Surgical Techniques
  • Animal Models

Background:

  • Implantation of electroencephalogram (EEG) electrodes in laboratory animals is typically time-consuming and requires specialized surgical equipment.
  • Existing methods often involve invasive procedures like skull drilling and screw placement, potentially impacting animal welfare and study efficiency.

Purpose of the Study:

  • To present a novel, rapid, and minimally invasive method for EEG electrode implantation in mice.
  • To demonstrate the efficacy and comparability of EEG recordings obtained using the new needle electrode technique versus traditional screw electrodes.

Main Methods:

  • Utilized thin, hook-shaped needle electrodes inserted into the skull without drilling or screw placement.
  • Secured electrodes with dental composite, allowing for surgical completion in under 15 minutes.
Keywords:
ElectrocorticogramElectroencephalogramElectromyogramMicePower spectrumSleep

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Last Updated: Jun 27, 2026

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  • Allowed animals to recover from anesthesia post-implantation.

    • Main Results:

    • The novel needle electrode implantation method is significantly faster (<15 min) and less invasive than traditional techniques.
    • EEG recordings obtained with needle electrodes were found to be comparable in quality to those from screw electrodes.
    • The procedure simplifies electrode placement and reduces overall implantation time.

    Conclusions:

    • This new method offers a faster, simpler, and more animal-welfare-friendly approach to EEG electrode implantation in mice.
    • The technique maintains the quality of EEG recordings, making it a viable alternative for research studies.
    • Enhances the accuracy and efficiency of EEG recording studies.