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Cardiometabolic Index: a novel prognostic biomarker for recurrent stroke risk in acute ischemic stroke patients

Yue Wang1,2,3, Yingying Ding4, Min Han1

  • 1Department of Neurosurgery, The First Affiliated Hospital of Shandong First Medical University and Shandong Provincial Qianfoshan Hospital, Jinan, Shandong Province, China.

Frontiers in Neurology
|June 26, 2026
PubMed

Insights

The Cardiometabolic Index (CMI) effectively predicts adverse cerebrovascular events in acute ischemic stroke (AIS) patients post-thrombolysis, outperforming traditional biomarkers. CMI offers improved risk stratification for better patient outcomes.

Area of Science:

  • Cardiology
  • Neurology
  • Biomarker Research

Background:

  • Stroke is a leading global health issue, with recurrent strokes posing significant risks for acute ischemic stroke (AIS) patients.
  • Predicting major adverse cerebrovascular events (MACEs) after thrombolysis is crucial for improving patient prognosis and reducing healthcare burdens.

Purpose of the Study:

  • To evaluate the Cardiometabolic Index (CMI) as a predictor of long-term adverse cerebrovascular events in AIS patients undergoing thrombolysis.
  • To compare the predictive efficacy of CMI against traditional biomarkers for MACEs.

Main Methods:

  • Retrospective analysis of 588 AIS patients who received thrombolytic therapy.
  • Multivariate analysis to determine the independent correlation between CMI and MACE risk.
  • Investigation into the mediating role of systemic inflammation in the CMI-outcome association.

Main Results:

  • CMI showed superior predictive performance for long-term adverse cerebrovascular events compared to conventional biomarkers.
  • A high CMI (≥0.80) was independently associated with an increased risk of MACEs.
  • Systemic inflammation partially mediated the predictive impact of CMI on adverse outcomes.

Conclusions:

  • CMI is a promising prognostic biomarker for predicting adverse cerebrovascular events in AIS patients post-thrombolysis.
  • CMI's ability to reflect metabolic and inflammatory status enhances risk stratification and personalized treatment.
  • Further large-scale studies are needed to confirm CMI's clinical utility and refine AIS therapeutic strategies.
Abstract

Keywords:
AISCardiometabolic Indexbiomarkerischemic strokemajor adverse cerebrovascular events

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