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Updated: Jun 27, 2026

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
Published on: October 14, 2021
Sézary Syndrome: Survival Trends, Racial Disparities, and Limited Prognostic Value of Routine Registry Variables.
Tiantian Zhang1, Weili Xue2, Zhe Wang3
1Department of Internal Medicine University of Central Florida Pensacola Florida USA.
Sézary syndrome (SS), a rare T-cell lymphoma, remains lethal with limited outcome data. Survival has improved, but racial disparities persist, and current models offer poor prognostic value.
Area of Science:
- Oncology
- Hematology
- Epidemiology
Background:
- Sézary syndrome (SS) is a rare leukemic cutaneous T-cell lymphoma.
- Limited contemporary population-level outcome data exists for SS.
Purpose of the Study:
- Evaluate survival trends and disparities in Sézary syndrome.
- Assess the prognostic value of routine registry variables using advanced modeling.
Main Methods:
- Utilized the SEER-22 database to identify 403 adults with primary SS (2000-2021).
- Analyzed overall survival (OS), 5-year OS, and adjusted mortality.
- Employed machine-learning and conventional models for prognostic assessment.
Main Results:
- Median OS was 48 months; 5-year OS was 42.7%.
- Survival improved significantly between 2000-2010 (39.5 months) and 2011-2021 (56.0 months).
- Black patients were diagnosed younger and exhibited worse adjusted mortality compared to White patients. Models showed limited predictive discrimination.
Conclusions:
- Sézary syndrome remains a highly lethal malignancy.
- Persistent racial disparities in mortality exist.
- Routine registry variables have limited prognostic value for SS.
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