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Updated: Jun 27, 2026

Protocols for Robust Herbicide Resistance Testing in Different Weed Species
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Potent and Receptor-Selective Germination Inhibitor for Striga hermonthica.

Michio Kuruma1,2, Masahiko Yoshimura3,4,5, Yuichiro Tsuchiya3,4

  • 1RIKEN Center for Sustainable Resource Science, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.

Precision Chemistry
|June 26, 2026
PubMed
Summary

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Researchers identified a compound that inhibits the germination of Striga hermonthica, a parasitic weed. This discovery offers a potential strategy to control the weed, which threatens food security in Africa.

Area of Science:

  • Agricultural Science
  • Plant Biology
  • Parasitic Weed Research

Background:

  • Striga hermonthica is a major parasitic weed impacting African crops.
  • Its germination is triggered by host-derived strigolactones (SLs) perceived by the ShHTL receptor protein.
  • Controlling Striga is crucial for food security and poverty reduction in Africa.

Purpose of the Study:

  • To identify inhibitors of the SL receptor in Striga.
  • To develop novel strategies for suppressing Striga hermonthica infestation.

Main Methods:

  • High-throughput screening of 800 compounds against ShHTL receptor proteins (ShHTL4-11).
  • Striga germination assays to test inhibitory activity.
  • Structure-activity relationship studies to optimize lead compounds.
Keywords:
chemical biologyinhibitorparasitic plantsplant hormonestrigolactone

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  • In vitro binding assays to determine receptor specificity.

    • Main Results:

    • 22 ShHTL antagonists were identified from the compound screen.
    • One compound demonstrated inhibitory activity against SL-induced Striga germination.
    • The optimized compound, SGM-3, selectively binds to ShHTL7, a key receptor for Striga germination.
    • SGM-3 exhibits higher potency in modulating Striga germination.

    Conclusions:

    • SGM-3 is a potent modulator of Striga germination, targeting the ShHTL7 receptor.
    • This compound holds promise for developing new methods to suppress Striga hermonthica.
    • Further research on SGM-3 can elucidate Striga parasitization mechanisms.