Localized stiffness programming enables tunable spatial control of vascular density in 3D hydrogels
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Updated: Jun 28, 2026
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3D Bioprinting Phototunable Hydrogels to Study Fibroblast Activation
Published on: June 30, 2023
He Li1, Fiona Louis1,2, Oju Jeon3
1Department of Applied Chemistry, Graduate School of Engineering, the University of Osaka, 2-1 Yamadaoka, Suita, Osaka, 565-0871, Japan. m-matsus@chem.eng.osaka-u.ac.jp.
Chemical Communications (Cambridge, England)
|June 26, 2026
Abstract:
We report an in situ light-mediated reinforcement strategy for spatial microvascular patterning. Laser-patterned stiff zones in AlgMA/fibrin hydrogels suppress capillary formation by >81%. A linear stiffness-density relationship (R2 > 0.78) enables predictable engineering of heterogeneous tissue architecture.
