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Updated: Jun 28, 2026

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation
Published on: January 16, 2019
MTA2: Decoding pathogenic mechanisms, clinical implications and therapeutic frontiers across disease landscapes
Hao Xie1, Ling Chen2, Jing Gou3
1Department of Radiology, West China Hospital Sichuan University Jintang Hospital, Jintang First People's Hospital, Chengdu, Sichuan 610400, P.R. China.
Abstract:
Metastasis‑associated protein 2 (MTA2), a crucial member of the metastasis‑associated family of transcriptional regulators, serves as a core component of the Mi‑2/nucleosome remodeling and deacetylase complex. It contributes to diverse human diseases through epigenetic regulation and integration of multiple signaling pathways. This paper systematically reviews the molecular and structural properties of MTA2 and investigates its functional mechanisms in both oncological and non‑oncological contexts, focusing on breast cancer, gastric cancer and hepatocellular carcinoma, emphasizing its biological roles in cancer metastasis, drug resistance and tumor microenvironment remodeling. Building on existing research, the review highlights the clinical significance of MTA2 as a potential diagnostic marker and therapeutic target in cancer and discusses targeted intervention strategies aimed at the MTA2‑related regulatory network. Finally, the development of highly specific inhibitors targeting MTA2 and the establishment of rapid MTA2 detection techniques for real‑time intraoperative margin assessment will fully unlock the clinical potential of MTA2.
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