Asymmetric synthesis of 3,3-disubstituted oxindoles: methodologies and applications in natural product synthesis
Rui Yang1, Lihua Wei1, Zhiqiang Ma1,2,3
1Key Lab of Functional Molecular Engineering of Guangdong Province, School of Chemistry & Chemical Engineering, South China University of Technology, Guangzhou 510641, China. cezqma@scut.edu.cn.
Abstract:
Covering: 1991 to 2026Chiral 3,3-disubstituted indoline scaffolds represent privileged structural motifs in indoline alkaloids. The asymmetric synthesis of 3,3-disubstituted oxindoles has emerged as a pivotal route for accessing such indoline frameworks. Over the past two decades, significant efforts have been devoted to developing novel asymmetric methodologies for this purpose. Several of these approaches have been successfully applied in the total synthesis of natural products. This review focuses on advances in these asymmetric methodologies and their applications in natural product synthesis.
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