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Related Concept Videos

Chirality in Nature02:30

Chirality in Nature

Chirality is the most intriguing yet essential facet of nature, governing life’s biochemical processes and precision. It can be observed from a snail shell pattern in a macroscopic world to an amino acid, the minutest building block of life. Most of the snails around the world have right-coiled shells because of the intrinsic chirality in their genes. All the amino acids present in the human body exist in an enantiomerically pure state, except for glycine - the sole achiral amino acid. The...
Chirality02:25

Chirality

Chirality is a term that describes the lack of mirror symmetry in an object. In other words, chiral objects cannot be superposed on their mirror images. For example, our feet are chiral, as the mirror image of the left foot, the right foot, cannot be superposed on the left foot.
Chiral objects exhibit a sense of handedness when they interact with another chiral object. For example, our left foot can only fit in the left shoe and not in the right shoe. Achiral objects — objects that have...
Molecules with Multiple Chiral Centers02:25

Molecules with Multiple Chiral Centers

Molecules that possess multiple chiral centers can afford a large number of stereoisomers. For instance, while some molecules like 2-butanol have one chiral center, defined as a tetrahedral carbon atom with four different substituents attached, several molecules like butane-2,3-diol have multiple chiral centers. A simple formula to predict the number of stereoisomers possible for a molecule with n chiral centers is 2n. However, there can be a lower number where some of the stereoisomers are...
Prochirality02:05

Prochirality

The concept of prochirality leads to the nomenclature of the individual faces of a molecule and plays a crucial role in the enantioselective reaction. It is a concept where two or more achiral molecules react to produce chiral products. A typical process is the reaction of an achiral ketone to generate a chiral alcohol. Here, the achiral reactant reacts with an achiral reducing agent, sodium borohydride, to generate an equimolar mixture of the chiral enantiomers of the product. For example, an...
Chirality at Nitrogen, Phosphorus, and Sulfur02:30

Chirality at Nitrogen, Phosphorus, and Sulfur

Chirality is most prevalent in carbon-based tetrahedral compounds, but this important facet of molecular symmetry extends to sp3-hybridized nitrogen, phosphorus and sulfur centers, including trivalent molecules with lone pairs. Here, the lone pair behaves as a functional group in addition to the other three substituents to form an analogous tetrahedral center that can be chiral.
A consequence of chirality is the need for enantiomeric resolution. While this is theoretically possible for all...
Molecular Shapes01:18

Molecular Shapes

Molecules have characteristic shapes that are crucial for their function. The arrangement of various electron groups around the central atom dictates their molecular geometry. Electron pairs in the valence shell of a central atom will adopt an arrangement that minimizes repulsions between the electron pairs by maximizing the distance between them. The valence electrons form either bonding pairs, located primarily between bonded atoms, or lone pairs.Two regions of electron density in a diatomic...

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Skeletal rearrangement of [4]helicenes under acidic conditions: dynamic chirality and improved properties by subsequent peripheral editing.

Chemical science·2026
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Densely-functionalized bicyclic cyclopentanones by combined photoinduced 6-<i>endo-trig</i> Giese additions and mild aldol cyclizations.

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Mitochondria-Targeted Delivery of siRNA by Amphiphilic Nanovectors Self-Assembled from a Cationic [4]Helicene-Squalene Ester.

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Related Experiment Video

Updated: Jun 28, 2026

An Electrochemical Cholesteric Liquid Crystalline Device for Quick and Low-Voltage Color Modulation
10:33

An Electrochemical Cholesteric Liquid Crystalline Device for Quick and Low-Voltage Color Modulation

Published on: February 27, 2019

When Chiral Molecular Design Shapes Light-Matter Interactions.

Bibiana Fabri1, Nidal Saleh2, Jérôme Lacour3

  • 1Organic Chemistry Dept., University of Geneva, Quai Ernest Ansermet 30, CH-1211 Geneva 4. bibiana.fabri@unige.ch.

Chimia
|June 26, 2026
PubMed
Summary
This summary is machine-generated.

Researchers explored chiral molecules like helicenes and macrocycles to control light interactions. These platforms tune photophysical and chiroptical properties, enabling advanced spectroscopic studies.

Keywords:
Asymmetric inductionBoramidinesCationic helicenesChiralityCircular dichroismCircularly polarised luminescenceMacrocyclesYlides

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Coulomb Explosion Imaging as a Tool to Distinguish Between Stereoisomers
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Coulomb Explosion Imaging as a Tool to Distinguish Between Stereoisomers

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Assembly of Gold Nanorods into Chiral Plasmonic Metamolecules Using DNA Origami Templates
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Assembly of Gold Nanorods into Chiral Plasmonic Metamolecules Using DNA Origami Templates

Published on: March 5, 2019

Related Experiment Videos

Last Updated: Jun 28, 2026

An Electrochemical Cholesteric Liquid Crystalline Device for Quick and Low-Voltage Color Modulation
10:33

An Electrochemical Cholesteric Liquid Crystalline Device for Quick and Low-Voltage Color Modulation

Published on: February 27, 2019

Coulomb Explosion Imaging as a Tool to Distinguish Between Stereoisomers
08:51

Coulomb Explosion Imaging as a Tool to Distinguish Between Stereoisomers

Published on: August 18, 2017

Assembly of Gold Nanorods into Chiral Plasmonic Metamolecules Using DNA Origami Templates
09:17

Assembly of Gold Nanorods into Chiral Plasmonic Metamolecules Using DNA Origami Templates

Published on: March 5, 2019

Area of Science:

  • Organic Chemistry
  • Photochemistry
  • Spectroscopy

Background:

  • Chirality plays a crucial role in molecular recognition and biological processes.
  • Understanding light-matter interactions is key to developing new optical and electronic materials.

Purpose of the Study:

  • To highlight recent advances in chiral platforms for tuning photophysical and chiroptical properties.
  • To showcase the application of these platforms in advanced spectroscopic techniques.

Main Methods:

  • Synthesis of novel chiral platforms including cationic helicenes, ylide-derived macrocycles/heterocycles, and boramidines.
  • Utilizing circular dichroism (CD) and circularly polarized luminescence (CPL) spectroscopy.
  • Employing resolution techniques and chiral ion pairing strategies.
  • Investigating supramolecular assemblies and ultrafast/X-ray spectroscopy.

Main Results:

  • Demonstrated the tunability of photophysical and chiroptical properties using diverse chiral platforms.
  • Successfully applied these platforms in various advanced spectroscopic studies.
  • Extended the scope of chiral studies to supramolecular systems and ultrafast dynamics.

Conclusions:

  • The presented chiral platforms offer versatile tools for manipulating light-matter interactions.
  • These advancements open new avenues in chiroptical materials science and spectroscopy.