Related Experiment Video
Updated: Jun 28, 2026

A Rat Model of Compound Acne
Published on: November 1, 2024
Igf-1 in acne pathogenesis and inositol as possible adjuvant treatment of acne
Iryna Y Smolanka1, Roman R Yaremkevych1, Pavlo Y Lesyk2
1UZHHOROD NATIONAL UNIVERSITY, UZHHOROD, UKRAINE.
Objective:
Aim: To provide a comprehensive review of acne pathogenesis and data regarding inositol efficacy in targeting IGF-1 pathway and decreasing IGF-1 levels and find pathophysiological substantiation (rationale, reasoning) of inositol therapy feasibility in acne treatment.
Patients And Methods:
Materials and Methods: Search of literature was performed on PubMed, Scopus, ResearchGate to identify scientific publications that aimed to research the role of inositol in acne and IGF-1 in acne pathogenesis and treatment and were published between 1999 and 2024 yielding information about possible therapeutic approach targeting IGF-1 induced increased sebum production. Peer-reviewed full-text articles, systematic reviews and evidence-based guidelines were included.
Conclusion:
Conclusions: We provided a comprehensive review of acne pathogenesis and data regarding inositol efficacy in targeting IGF-1 pathway.
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