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Related Concept Videos

Protein Folding01:22

Protein Folding

Overview
Protein Folding01:22

Protein Folding

Overview
Protein Folding01:25

Protein Folding

Proteins are chains of amino acids linked together by peptide bonds. Upon synthesis, a protein folds into a three-dimensional conformation, critical to its biological function. Interactions between its constituent amino acids guide protein folding, and hence the protein structure is primarily dependent on its amino acid sequence.
Protein Structure Is Critical to Its Biological Function
Proteins perform a wide range of biological functions such as catalyzing chemical reactions, providing...
Protein Folding Quality Check in the RER01:29

Protein Folding Quality Check in the RER

ER is the primary site for the maturation and folding of soluble and transmembrane secretory proteins. The calnexin cycle is a specific chaperone system that folds and assesses the confirmation of N-glycosylated proteins before they can exit the ER lumen. The primary players of this quality check pipeline are the lectins, ER-resident chaperones, and a glucosyl transferase enzyme. In case the calnexin system in the lumen fails to salvage a misfolded protein, it is transported to the cytoplasm...
Protein and Protein Structure02:15

Protein and Protein Structure

Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
A protein's shape is critical to its function. For example, an enzyme can...
Protein Organization01:24

Protein Organization

Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence.

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Related Experiment Video

Updated: Jun 28, 2026

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web
09:51

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Published on: July 16, 2017

Foldify: Web Application for Protein Structure Prediction.

Romana Ďuráčiová1, Michaela Capandová1, Karel Berka2

  • 1Institute of Computer Science, Masaryk University, Brno 628 00, Czech Republic.

Journal of Chemical Information and Modeling
|June 26, 2026
PubMed
Summary
This summary is machine-generated.

Foldify simplifies protein structure prediction by integrating multiple advanced models (AlphaFold 3, AlphaFold 2, ColabFold, OmegaFold, ESMFold) into an accessible graphical interface. This tool enhances usability for researchers in structural biology.

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Application of I TASSER, trRosetta, UCSF Chimera, HADDOCK server, and HEX loria for De Novo and In Silico Design of Proteins

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Related Experiment Videos

Last Updated: Jun 28, 2026

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web
09:51

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

Published on: July 16, 2017

A Protocol for Computer-Based Protein Structure and Function Prediction
16:41

A Protocol for Computer-Based Protein Structure and Function Prediction

Published on: November 3, 2011

Application of I TASSER, trRosetta, UCSF Chimera, HADDOCK server, and HEX loria for De Novo and In Silico Design of Proteins
05:08

Application of I TASSER, trRosetta, UCSF Chimera, HADDOCK server, and HEX loria for De Novo and In Silico Design of Proteins

Published on: July 8, 2025

Area of Science:

  • Structural Biology
  • Computational Biology
  • Bioinformatics

Background:

  • Recent protein structure prediction models offer significant advancements but require substantial hardware and expertise.
  • Accessibility remains a barrier to widespread adoption of these powerful tools.

Purpose of the Study:

  • To present Foldify, a user-friendly graphical interface for accessing multiple protein structure prediction models.
  • To democratize the use of cutting-edge prediction tools like AlphaFold 3 and ESMFold.

Main Methods:

  • Integration of AlphaFold 3, AlphaFold 2, ColabFold, OmegaFold, and ESMFold into a single platform.
  • Development of a web-based graphical user interface for sequence submission and model execution.
  • Implementation of a scalable high-performance computing environment for stable operation.

Main Results:

  • Foldify provides a unified platform for executing diverse protein structure prediction models.
  • Users can visualize predicted structures online using Mol* Viewer or download them.
  • A multi-result comparison mode allows direct visualization and qualitative assessment of prediction similarity.

Conclusions:

  • Foldify significantly lowers the barrier to entry for utilizing advanced protein structure prediction models.
  • The platform enhances research accessibility and facilitates comparative analysis of different prediction methods.