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Direct measurement method for 90Y activity in urine.
Yan Ma1,2, Lina Ma1,2, Hui Zhang1,2
1China Institute for Radiation Protection, 102 Xuefu Street, Taiyuan City 030006, Shanxi Province, People's Republic of China. mayan@cirp.org.cn.
Analytical Methods : Advancing Methods and Applications
|June 26, 2026
Summary
Accurate measurement of Yttrium-90 (90Y) in urine is vital for radiation safety after radioembolization. Both liquid scintillation counting and Cherenkov counting methods offer reliable accuracy for determining 90Y activity in urine samples.
Area of Science:
- Nuclear medicine
- Radiochemistry
- Radiation safety
Background:
- Yttrium-90 (90Y) radioembolization treats unresectable hepatocellular carcinoma.
- Accurate monitoring of 90Y excretion in urine is essential for radiation safety.
- Urine analysis for 90Y activity requires sensitive and precise detection methods.
Purpose of the Study:
- To evaluate the feasibility of direct Yttrium-90 (90Y) activity determination in urine.
- To compare the performance of liquid scintillation counting (LSC) and Cherenkov counting methods.
- To investigate the impact of urine optical properties on counting efficiency and accuracy.
Main Methods:
- Comparison of liquid scintillation counting (LSC) and Cherenkov counting for 90Y detection in urine.
- Analysis of counting efficiency, background counts, and minimum detectable activity (MDA).
- Assessment of method accuracy using spiked urine samples with known 90Y concentrations.
Main Results:
- Counting efficiency for both LSC and Cherenkov counting positively correlated with urine light transmittance.
- LSC showed higher counting efficiency under similar light transmittance conditions.
- Cherenkov counting demonstrated lower background counts and MDA, performing better with high light transmittance.
Conclusions:
- Both LSC and Cherenkov counting provide reliable accuracy for 90Y determination in urine.
- Cherenkov counting offers advantages in sensitivity (lower MDA) under specific conditions.
- This study supports the reliable detection of 90Y in urine for radiation safety assessments.
