Related Experiment Video
Updated: Jun 28, 2026

Neutrophil Lifespan Extension with CLON-G and an In Vitro Spontaneous Death Assay
Published on: May 12, 2023
Chronic Neutropenia in Children: A Single-Center Experience.
Jelena Roganović1, Martina Zubović2, Ana Đorđević3
1Department of Pediatric Hematology and Oncology, Children's Hospital Zagreb, Zagreb, Croatia; Faculty of Biomedicine and Drug Development, University of Rijeka, Rijeka, Croatia. jelena.roganovic02@gmail.com; jelena.roganovic@kdbz.hr.
Pediatric chronic neutropenia, including autoimmune (AIN) and idiopathic (CIN) forms, typically has a mild course with most children achieving spontaneous remission. Genetic testing is crucial for suspected congenital neutropenia.
Area of Science:
- Pediatric Hematology
- Immunology
Background:
- Chronic neutropenia in children presents diagnostic and management challenges.
- Understanding the specific characteristics of autoimmune neutropenia (AIN) and chronic idiopathic neutropenia (CIN) is vital for effective patient care.
Purpose of the Study:
- To analyze the characteristics, etiology, diagnosis, management, follow-up, and outcomes of pediatric chronic neutropenia.
- To compare outcomes between AIN and CIN in a Croatian cohort.
Main Methods:
- Retrospective review of 48 children diagnosed with chronic neutropenia between 2013 and 2021.
- Analysis of demographic, clinical, and laboratory data, including absolute neutrophil count (ANC) and antineutrophil antibodies.
Main Results:
- Autoimmune neutropenia (AIN) and chronic idiopathic neutropenia (CIN) were the most common diagnoses.
- Most children (83%) achieved spontaneous remission within a median of 13.5 months.
- Lower ANC at diagnosis correlated with longer remission times and more hospitalizations.
Conclusions:
- Pediatric chronic isolated neutropenia generally has a mild clinical course with low infection rates.
- Spontaneous remission is common, often occurring within a year.
- Genetic testing is recommended for suspected congenital neutropenia; adherence to European guidelines improves care.
Related Concept Videos
Pharmacokinetics in Pediatric Patients: Drug Excretion
Pharmacokinetics in Pediatric Patients: Drug Distribution
Bone Marrow Sampling and Transplants
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
Pharmacokinetics in Pediatric Patients: Drug Metabolism
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption
