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Updated: Jun 28, 2026

Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model
Published on: June 6, 2025
[Clinical application of antidepressants: Advantages and opportunities for individual drugs]
U P Sivolap1, V D Mendelevich2
1Peoples' Friendship University of Russia named after Patrice Lumumba, Moscow, Russia.
Abstract:
Antidepressants rank among the most frequently prescribed medications globally, a trend attributed to their efficacy in managing major depressive disorder, other forms of depressive states, anxiety disorders, and various mental health conditions. Furthermore, antidepressants demonstrate several non-psychotropic pharmacological effects, which broaden their potential applications beyond psychiatry into general medical practice. This article presents essential information regarding the pharmacological spectrum, effectiveness, and safety profiles of diverse antidepressants, with a particular focus on escitalopram, duloxetine, and mirtazapine.
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Benzodiazepines bind to the GABA-A receptor in the brain, enhancing GABA's interaction. This action reduces neurotransmission, effectively blocking anxiety-associated limbic circuitry.
