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Related Concept Videos

Protein Complex Assembly02:41

Protein Complex Assembly

Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types.  Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
Many viruses self-assemble into a fully functional unit using the infected host cell to...
Protein Complex Assembly02:41

Protein Complex Assembly

Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types.  Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
Many viruses self-assemble into a fully functional unit using the infected host cell to...
Protein-protein Interfaces02:04

Protein-protein Interfaces

Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a polypeptide...
Assembly of Cytoskeletal Filaments01:18

Assembly of Cytoskeletal Filaments

Cytoskeletal filaments are polymeric forms of smaller protein subunits. However, individual cytoskeletal filaments may easily disassemble or associate with other similar filaments to form rigid structures. Microfilaments, made of actin monomers, rely on actin-binding proteins to form bundles and create networks of individual actin filaments. Microtubules rely on microtubule-associated proteins (MAPs) to form sturdy cylindrical structures. However, the proteins involved in forming complex...
Protein Complexes with Interchangeable Parts01:57

Protein Complexes with Interchangeable Parts

Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order to...
Protein Complexes with Interchangeable Parts01:57

Protein Complexes with Interchangeable Parts

Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order to...

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Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules
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Controllable protein assembly: from design strategies to functional applications.

Xiaoxuan Yu1, Hui Li1, Xiaohua Du1

  • 1Key Laboratory of Organosilicon Chemistry and Material Technology Ministry of Education, College of Material Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 311121, China. wangtt@hznu.edu.cn.

Chemical Communications (Cambridge, England)
|June 26, 2026
PubMed
Summary

Artificial protein assembly mimics nature to create functional nanomaterials. This review covers assembly strategies, applications in biocatalysis and drug delivery, and future directions for intelligent protein materials.

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Area of Science:

  • Biochemistry and Materials Science
  • Synthetic Biology and Nanotechnology

Background:

  • Proteins are essential biological molecules that perform vital functions through self-assembly into complex structures.
  • Artificial protein assembly draws inspiration from natural systems to design and construct novel protein-based nanomaterials.

Purpose of the Study:

  • To systematically review recent advancements in artificial protein assembly.
  • To highlight key construction strategies and their applications.
  • To discuss future trends and challenges in the field.

Main Methods:

  • Supramolecular assembly strategies.
  • Covalent assembly strategies.
  • Computational design approaches.

Main Results:

  • These strategies enable precise control over protein nanostructures across multiple scales (1D to 3D).
  • Applications are expanding into fields like biocatalysis and drug delivery.
  • A significant trend is the shift from static protein structures to dynamic functional systems.

Conclusions:

  • Artificial protein assembly offers a powerful platform for developing intelligent biomaterials.
  • Overcoming challenges in predictability, multifunctional integration, and in vivo stability is crucial for future progress.
  • Continued research will drive the development of advanced protein-based materials for diverse applications.