Related Experiment Video

Updated: Jun 28, 2026

Suppression of Pro-fibrotic Signaling Potentiates Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts into Induced Cardiomyocytes
09:16

Suppression of Pro-fibrotic Signaling Potentiates Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts into Induced Cardiomyocytes

Published on: June 3, 2018

Functional rejuvenation of endothelial cell aging by transient reprogramming

Katrin Kalies1, Kai Knoepp2, Laura Hehl2

  • 1Mid-German Heart Center, Department of Internal Medicine III, Division of Cardiology, Angiology and Intensive Medical Care, University Hospital Halle, Martin-Luther-University Halle-Wittenberg, Ernst-Grube-Strasse 40, 06120, Halle (Saale), Germany. Katrin.Kalies@uk-halle.de.

Basic Research in Cardiology
|June 26, 2026
PubMed
Summary

Targeting senescent endothelial cells (ECs) can improve cardiovascular health. Non-genetic overexpression of Yamanaka factors partially rejuvenates ECs, reducing senescence and improving function in vitro and in vivo.

Keywords:
AngiogenesisCellular reprogrammingEndothelial dysfunctionSenescence

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