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Updated: Jun 28, 2026
Improved Hysteroscopic Resection of Endometrial Polyps Using 6-Fr Micro-Scissors and Forceps
Published on: August 2, 2024
GSDMD/Caspase-1-based evaluation of dydrogesterone in preventing recurrence after hysteroscopic endometrial
Kai Liu1, Chunyan Hu1, Liang Jia1
1Department of Gynecology II, Northwest Women's and Children's Hospital, Xian, Shaanxi, China.
Objective:
The research focuses on understanding how GSDMD and Caspase-1, key regulators of pyroptosis, influence postoperative recurrence in Endometrial Polyps (EPs) and examines whether a combined biomarker can effectively predict recurrence likelihood.
Methods:
264 EP patients (stratified post-surgery into dydrogesterone-treated and control groups) and 132 healthy women were included. Peripheral blood GSDMD-N, Caspase-1, and estrogen concentrations were quantified. Follow-up assessments at one-year post-operation were conducted to examine associations between these pyroptotic markers and clinical outcomes.
Results:
Increases in GSDMD-N and Caspase-1 were observed in EP patients versus healthy subjects (p < 0.05). A diagnostic AUC of 0.781 was determined for the joint model. Pyroptosis markers correlated positively with FSH//E2 and negatively with P (p < 0.05). Recurrent post-surgery cases had higher GSDMD-N/Caspase-1 than non-recurrent ones (p < 0.05); the predictive AUC of the combined model for recurrence reached 0.727.
Conclusion:
Post-EP recurrence correlates with GSDMD/Caspase-1 levels, and integrating these markers enhances recurrence risk assessment.
