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The gut microbiota, neurodevelopment and autism spectrum disorder: A close connection
Yuchao Guo1, Aikun Liu2, Xia Hao3
1State Key Laboratory of Component-Based Chinese Medicine, Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
None:
The gut microbiota plays a crucial role in early neurodevelopment, particularly during the highly adaptable prenatal and postnatal stages. Dysbiosis in these periods can disrupt the microbiota-gut-brain axis, hinder neural development, and increase the risk of autism spectrum disorder (ASD). This review examines how maternal and infant gut microbiota dysbiosis affects neurodevelopment, explores microbial differences in ASD children and their neurotypical siblings, and analyzes the link between microbial patterns and ASD severity. It also summarizes current microbiota-targeted therapies for ASD and their mechanisms. Overall, the review aims to connect maternal-infant gut microbiota, neurodevelopment, and ASD, providing insights for microbiota-based prevention and intervention strategies for ASD.
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