Related Experiment Video
Updated: Jun 28, 2026
Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study
Published on: August 15, 2025
Clinical and neuroimaging predictors of outcome and impact of surgical intervention in cryptococcal meningitis: An
Meng-Yi Qian1, Long-Yuan He1, Ping Lan1
1Department of Neurosurgery, The First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Background:
This study aimed to identify predictors of outcomes and evaluate the therapeutic impact of surgical intervention in CM patients, with a specific focus on the growing HIV-negative population in East Asia.
Methods:
We conducted a single-center retrospective cohort study. The primary outcome was the 12-month modified Rankin Scale (mRS) score. Multivariable ordinal logistic regression and propensity score matching (PSM) analysis were employed to identify independent predictors of outcome and evaluate the association with surgical intervention.
Results:
The cohort comprised 181 patients. The unfavorable outcome rate in HIV-negative group was higher than in the HIV-positive group (19.1% vs 5.0%). Impaired consciousness (OR: 5.51, 95% CI: 2.13-14.26), motor deficits (OR: 3.83, 95% CI: 1.42-10.35), and advanced age (OR: 2.04, 95% CI: 1.43-2.91) showed independent associations with unfavorable outcome. Hydrocephalus and periventricular edema showed trends toward worse outcomes in univariate analyses. After PSM, surgical intervention was associated with lower odds of unfavorable outcomes among patients with hydrocephalus or refractory intracranial hypertension (adjusted Odds Ratio 0.32; P = 0.011). Peak CSF pressure showed limited accuracy for long-term outcomes (AUC = 0.562).
Conclusion:
Clinical severity markers independently predicted 12-month outcomes, while surgical intervention was associated with improved prognosis in patients with CSF dynamic disorders.
