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Related Experiment Video

Updated: Jun 28, 2026

Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea

Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea

Published on: December 6, 2016

GLP-1 receptor agonists in obstructive sleep apnea: A propensity score-matched real-world analysis.

Pranjal Rai¹, Girish Bathla¹, Niharika Praveen¹

¹Department of Radiology, Mayo Clinic, 200 1st Street Southwest, Rochester, MN, 55902, USA.

Respiratory Medicine

|June 26, 2026

Summary

Glucagon-like peptide-1 receptor agonists (GLP-1As) show promise in reducing cerebrovascular events and mortality in obstructive sleep apnea (OSA) patients. These findings suggest GLP-1As may be beneficial adjuncts to standard OSA care.

Keywords:

GLP-1 receptor agonist Healthcare utilization Mortality Obstructive sleep apnea Stroke

Related Experiment Videos

Last Updated: Jun 28, 2026

Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea

Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea

Published on: December 6, 2016

Area of Science:

Cardiovascular Science
Endocrinology
Sleep Medicine

Background:

Obstructive sleep apnea (OSA) is linked to poor cerebrovascular outcomes.
Glucagon-like peptide-1 receptor agonists (GLP-1As) have demonstrated cerebrovascular benefits in diabetes and obesity.
Long-term GLP-1A effects in OSA patients remain unclear.

Purpose of the Study:

To investigate the long-term impact of GLP-1A exposure on cerebrovascular events and mortality in adults with OSA.
To assess the association between GLP-1A use and healthcare utilization in OSA patients.

Main Methods:

Retrospective cohort study using the TriNetX US Collaborative Network (2016-2025).
Identified adults with OSA and analyzed GLP-1A initiation.
Utilized propensity score matching (1:1) and assessed outcomes at 1, 3, and 5 years.

Main Results:

GLP-1A exposure was linked to significantly lower hazards of ischemic stroke, intracranial hemorrhage, and all-cause mortality.
Reduced emergency department visits and inpatient hospitalizations were observed with GLP-1A use.
Consistent associations were found in CPAP-restricted and tirzepatide-specific subgroup analyses.

Conclusions:

GLP-1A exposure is associated with reduced cerebrovascular events, healthcare utilization, and mortality in a large OSA cohort.
Findings are hypothesis-generating, suggesting potential benefits of incretin-based therapies in OSA management.
Prospective studies are needed to validate these real-world observations.