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Updated: Jun 28, 2026
09:09
High Throughput, Real-time, Dual-readout Testing of Intracellular Antimicrobial Activity and Eukaryotic Cell Cytotoxicity
Published on: November 16, 2016
Non-antibiotic drug-induced microbiotoxicity as a pharmacological variable.
Tingting Pan1, Heping Yang1, Chunyan Yang2
1College of Biology Pharmacy and Food Engineering, Qinling Institute of Biological Resources, Shangluo University, Shangluo, 726000, PR China.
Chemico-Biological Interactions
|June 26, 2026
Summary
Non-antibiotic drugs disrupt the gut microbiota, impacting drug efficacy and toxicity. Understanding pharmacomicrobiomics and microbiotoxicity is crucial for personalized medicine and predicting adverse drug reactions.
Area of Science:
- Pharmacology
- Microbiology
- Drug Metabolism
Background:
- Traditional pharmacology inadequately explains drug efficacy and toxicity variations.
- Gut microbiota influences drug exposure, efficacy, and adverse reactions.
- Gut microbiota plays a direct role in drug biotransformation.
Purpose of the Study:
- To review mechanisms of gut microbiota disruption by non-antibiotic drugs.
- To explore the concept of pharmacomicrobiomics and microbiotoxicity.
- To discuss clinical implications of drug-induced microbiota changes.
Main Methods:
- Systematic review of primary mechanisms.
- Integration of evidence from various drug classes (metabolic, neuropsychiatric, etc.).
- Conceptual analysis of pharmacomicrobiomics and microbiotoxicity.
Main Results:
- Non-antibiotic drugs induce gut microbiota disruption through various mechanisms.
- Gut microbiota alterations affect drug metabolite profiles, barrier function, immunity, and ADME systems.
- Evidence spans metabolic, neuropsychiatric, gastrointestinal, anticancer, and immunomodulatory drugs.
Conclusions:
- Drug-induced microbiotoxicity is a critical factor in pharmacology.
- Pharmacological frameworks must incorporate host microbiome impact.
- Future drug evaluation requires consideration of microbiome interactions for precision medicine.
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