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Updated: Jun 28, 2026

Z-Scores for Assessing Ovarian Reserve in Young Patients Undergoing Fertility Preservation
Published on: October 25, 2024
Different managements of the same disease- malignant ovarian germ cell tumor treated by pediatric or gynecologic
Wen-Hsuan Lin1, Ting-Chi Yeh2, Hsi-Che Liu2
1Department of Obstetrics & Gynecology, MacKay Memorial Hospital, Taipei, Taiwan.
Objective:
The surgical approach, staging system, including the criteria for adjuvant chemotherapy and even the chemotherapeutic regimens between Pediatric and Gynecologic oncologists are different for the same disease-malignant ovarian germ cell tumors (MOGCTs). This study is to review the differences with regard to the survival and re-appraise each mode of treatment.
Materials And Methods:
A retrospective review of medical records of the patients with malignant germ cell tumor in Mackay Memorial Hospital between 1997-2017 were performed. We re-staged the patients in pediatric group from COG stage system to FIGO stage system and documented the disease survival rate in different staging system. Accordingly, treatment outcomes were compared by progression-free survival rate, using Kaplan-Meier method.
Results:
87 patients with MOGCTs were analyzed. 67 cases were managed by gynecologists and 20 cases by pediatricians. There were no significant differences of the progression-free survival rate at 10 years in patients with conservative surgery or fertility-sparing staging operation (p = 0.947). Ten-year progression free survival rate in patient receiving chemotherapy with BEP regimen (bleomycin + etoposide + cisplatin) was 97.8% and in JEB regimen (bleomycin + etoposide + carboplatin) was 77.8% (p = 0.003).
Conclusion:
The survival rates are similar between patients receiving conservative surgical approach or complete staging operation. It might be due to the high chemosensitivity nature of these diseases. However, our data suggest cisplatin is more effective than carboplatin in high-risk group.
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