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Related Concept Videos

Biofilms01:29

Biofilms

Biofilms are complex communities of microorganisms encased in a self-produced extracellular polysaccharide matrix attached to surfaces. These microbial consortia can include single or multiple species, providing enhanced survival benefits by forming organized, multilayered structures.The formation of biofilms occurs through four key stages: attachment, colonization, development, and dispersal.During attachment, free-swimming planktonic cells adhere to a surface, often facilitated by...
Bacterial Signaling01:30

Bacterial Signaling

Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...
Production of Biopesticides01:18

Production of Biopesticides

Biopesticides offer a sustainable alternative to chemical pesticides, utilizing microbial agents to control agricultural pests. Bacillus thuringiensis (Bt) is a widely employed bacterium known for its potent insecticidal activity. Bt biopesticides are favored for their specificity to insect pests, minimal environmental impact, and natural degradability.Mechanism of Bt Toxin Action Bt produces insecticidal crystal (Cry) proteins during its sporulation phase. These proteins form parasporal...
Bioreactor Design and Operational System01:29

Bioreactor Design and Operational System

Bioreactors are engineered vessels designed to cultivate microorganisms under controlled conditions for industrial bioprocessing. They maintain sterility and allow precise regulation of pH, temperature, oxygen, and nutrient levels to optimize microbial growth and metabolite production. Bioreactors range from small laboratory units of 1 liter to industrial systems holding up to 500,000 liters, though only about 75% of their volume is actively used for fermentation. The remaining headspace...
Biological Methods for Microbial Control01:28

Biological Methods for Microbial Control

Biological agents offer an effective means of controlling microbial growth by leveraging natural processes like predation, competition, and the secretion of antimicrobial substances.Predatory bacteria such as Bdellovibrio species target and kill pathogens like Salmonella and E. coli. They are widely used in poultry farms to control infections. Myxococcus species help combat plant-pathogenic fungi. These naturally occurring predators serve as eco-friendly alternatives to chemical pesticides and...

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Related Experiment Video

Updated: Jun 28, 2026

Three-dimensional Patterning of Engineered Biofilms with a Do-it-yourself Bioprinter
08:40

Three-dimensional Patterning of Engineered Biofilms with a Do-it-yourself Bioprinter

Published on: May 16, 2019

Engineered bacterial biofilms for biotechnological applications.

Nona Hashemi1, Karen O Osiro2, Octavio L Franco3

  • 1Department of Nanoengineering, Joint School of Nanoscience and Nanoengineering, North Carolina A&T State University, Greensboro, NC, 27401, USA.

Trends in Biotechnology
|June 26, 2026
PubMed
Summary

Engineered bacterial biofilms (EBBs) are living materials modified for specific functions in manufacturing, agriculture, and health. This review outlines their design, applications, and a framework for developing reliable biofilm technologies.

Keywords:
biofilm life cycleengineered bacterial biofilmsengineered living materialsmicrobial biosensingsynthetic biology

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Last Updated: Jun 28, 2026

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Published on: November 16, 2012

Area of Science:

  • Synthetic biology
  • Microbial biotechnology
  • Materials science

Background:

  • Bacterial biofilms are living materials with useful properties like surface attachment and stress tolerance.
  • Bioengineering advances highlight biofilms' potential for biotechnological applications.
  • Engineered bacterial biofilms (EBBs) are genetically modified to perform specific functions.

Purpose of the Study:

  • To define engineered bacterial biofilms (EBBs).
  • To present case studies of EBB engineering and applications.
  • To propose a life cycle framework for EBB development.

Main Methods:

  • Review of current literature on engineered bacterial biofilms.
  • Analysis of EBB engineering strategies and application examples.
  • Development of a conceptual framework for biofilm technology development.

Main Results:

  • EBBs are defined as biofilms from engineered bacterial chassis and genes for specific functions.
  • Representative case studies showcase EBB engineering and diverse applications.
  • A biofilm life cycle framework (preformation, formation, postformation) is proposed.

Conclusions:

  • EBBs offer a promising platform for sustainable manufacturing, environmental monitoring, agriculture, and health.
  • Design principles, enabling tools, and translational barriers are highlighted for developing reliable EBB technologies.
  • Further research and development are needed to overcome barriers and realize the full potential of biofilm technologies.