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  1. Home
  3. Sex Differences In Insular Cortex Function In Persistent Alcohol Drinking Despite Aversion In Mice.
  1. Home
  3. Sex Differences In Insular Cortex Function In Persistent Alcohol Drinking Despite Aversion In Mice.

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Sex differences in insular cortex function in persistent alcohol drinking despite aversion in mice.

Claudia Fornari1,2, Daria Ricci1, Yoni Couderc1

  • 1University of Bordeaux, INSERM 1215, Neurocentre Magendie, 146 rue Léo Saignat, 33000, Bordeaux, France.

Molecular Psychiatry
|June 26, 2026

View abstract on PubMed

Summary
This summary is machine-generated.

Female mice exhibit higher alcohol binge drinking and persistence despite aversion. The posterior insular cortex (pIC) shows sex-specific roles in this persistent drinking, offering insights into alcohol use disorder (AUD) neurobiology.

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Related Experiment Videos

Modeling Alcohol Consumption in Rodents Using Two-Bottle Choice Home Cage Drinking and Microstructural Analysis
08:45

Modeling Alcohol Consumption in Rodents Using Two-Bottle Choice Home Cage Drinking and Microstructural Analysis

Published on: November 8, 2024

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder
05:12

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder

Published on: June 23, 2023

Area of Science:

  • Neurobiology
  • Behavioral Neuroscience
  • Addiction Research

Background:

  • Alcohol use disorder (AUD) is characterized by persistent drinking despite negative consequences.
  • Binge drinking is a significant risk factor for AUD, with narrowing sex gaps in prevalence.
  • The insular cortex (IC), comprising anterior (aIC) and posterior (pIC) regions, is implicated in AUD, but its sex-specific roles in binge and persistent drinking are unclear.

Purpose of the Study:

  • To investigate sex differences in alcohol binge drinking and the persistence of ethanol consumption despite aversion.
  • To elucidate the distinct roles of the anterior (aIC) and posterior (pIC) insular cortex in the neurobiology of alcohol consumption, considering sex-specific effects.

Main Methods:

  • Utilized the 'drinking in the dark' mouse model to assess ethanol intake.
  • Administered ethanol mixed with quinine to evaluate persistent drinking under aversive conditions.
  • Employed fiber photometry to record neural activity in the aIC and pIC.
  • Used chemogenetics to manipulate glutamatergic neuron activity in the aIC and pIC.

Main Results:

  • Female mice showed significantly higher binge ethanol intake and persistent drinking when ethanol was adulterated with quinine compared to males.
  • Anterior insular cortex (aIC) activity increased during binge and persistent ethanol consumption in both sexes.
  • Posterior insular cortex (pIC) glutamatergic neuron activity was elevated during persistent ethanol drinking specifically in females.
  • Inhibition of aIC neurons reduced bitter solution intake irrespective of sex or solvent.
  • Inhibition of pIC neurons selectively reduced persistent ethanol drinking in females and quinine consumption in males.

Conclusions:

  • The posterior insular cortex (pIC) plays a sex-dependent role in the persistence of ethanol consumption, particularly in females.
  • These findings highlight sex-specific functions of the insular cortex subdivisions in the neurobiological underpinnings of alcohol use disorder (AUD).
  • The study provides a foundation for understanding sex-specific neural mechanisms in AUD and developing targeted interventions.