Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Jun 28, 2026

Modeling Alcohol Consumption in Rodents Using Two-Bottle Choice Home Cage Drinking and Microstructural Analysis

Modeling Alcohol Consumption in Rodents Using Two-Bottle Choice Home Cage Drinking and Microstructural Analysis

Published on: November 8, 2024

Sex differences in insular cortex function in persistent alcohol drinking despite aversion in mice.

Claudia Fornari^1,2, Daria Ricci¹, Yoni Couderc¹

¹University of Bordeaux, INSERM 1215, Neurocentre Magendie, 146 rue Léo Saignat, 33000, Bordeaux, France.

Molecular Psychiatry

|June 26, 2026

Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

DUSTrack: Semi-automated point tracking in ultrasound videos.

Scientific reports·2026

Same author

A multimodal biomechanics dataset with synchronized kinematics and internal tissue motions during reaching.

Scientific data·2026

Same author

Non-contact radar assessment of One-Legged Stand Test for fall risk in aging.

Gait & posture·2026

Same author

The biomechanics of piano playing: a systematic review of kinematic, kinetic, and electromyographic literature.

Frontiers in psychology·2026

Same author

Efficient elastic tissue motions indicate general motor skill.

Scientific reports·2025

Same author

The multifaceted role of microRNAs in colorectal cancer: pathogenesis and therapeutic implications.

Non-coding RNA research·2025

Same journal

Towards ecological psychiatry: The herbicide glyphosate disrupts behavior through microbiota-gut-brain axis.

Molecular psychiatry·2026

Same journal

BDNF-DT and BDNF-AS-DT: novel genes in the BDNF locus.

Molecular psychiatry·2026

Same journal

Serotonergic SLC10A4 regulates extracellular serotonin levels and antidepressant responsiveness.

Molecular psychiatry·2026

Same journal

TranDep: a transcriptomics atlas of depression.

Molecular psychiatry·2026

Same journal

Effects of cannabidiol on anxiety- and depressive-like behaviors and cognition: a systematic review and meta-analysis of preclinical studies.

Molecular psychiatry·2026

Same journal

Genome-wide genetic overlap between fear-based disorders and generalised anxiety disorder.

Molecular psychiatry·2026

See all related articles

This summary is machine-generated.

Female mice exhibit higher alcohol binge drinking and persistence despite aversion. The posterior insular cortex (pIC) shows sex-specific roles in this persistent drinking, offering insights into alcohol use disorder (AUD) neurobiology.

Area of Science:

Neurobiology
Behavioral Neuroscience
Addiction Research

Background:

Alcohol use disorder (AUD) is characterized by persistent drinking despite negative consequences.
Binge drinking is a significant risk factor for AUD, with narrowing sex gaps in prevalence.
The insular cortex (IC), comprising anterior (aIC) and posterior (pIC) regions, is implicated in AUD, but its sex-specific roles in binge and persistent drinking are unclear.

Purpose of the Study:

To investigate sex differences in alcohol binge drinking and the persistence of ethanol consumption despite aversion.
To elucidate the distinct roles of the anterior (aIC) and posterior (pIC) insular cortex in the neurobiology of alcohol consumption, considering sex-specific effects.

Main Methods:

Utilized the 'drinking in the dark' mouse model to assess ethanol intake.

More Related Videos

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder

Published on: June 23, 2023

Related Experiment Videos

Last Updated: Jun 28, 2026

Modeling Alcohol Consumption in Rodents Using Two-Bottle Choice Home Cage Drinking and Microstructural Analysis

Modeling Alcohol Consumption in Rodents Using Two-Bottle Choice Home Cage Drinking and Microstructural Analysis

Published on: November 8, 2024

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder

Published on: June 23, 2023

Administered ethanol mixed with quinine to evaluate persistent drinking under aversive conditions.

Employed fiber photometry to record neural activity in the aIC and pIC.

Used chemogenetics to manipulate glutamatergic neuron activity in the aIC and pIC.

Main Results:

Female mice showed significantly higher binge ethanol intake and persistent drinking when ethanol was adulterated with quinine compared to males.
Anterior insular cortex (aIC) activity increased during binge and persistent ethanol consumption in both sexes.
Posterior insular cortex (pIC) glutamatergic neuron activity was elevated during persistent ethanol drinking specifically in females.
Inhibition of aIC neurons reduced bitter solution intake irrespective of sex or solvent.
Inhibition of pIC neurons selectively reduced persistent ethanol drinking in females and quinine consumption in males.

Conclusions:

The posterior insular cortex (pIC) plays a sex-dependent role in the persistence of ethanol consumption, particularly in females.
These findings highlight sex-specific functions of the insular cortex subdivisions in the neurobiological underpinnings of alcohol use disorder (AUD).
The study provides a foundation for understanding sex-specific neural mechanisms in AUD and developing targeted interventions.