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Concise synthesis and strain-release diversification of bridgehead-substituted [2]-ladderanes

Zongbin Jia1, Hugo A Salazar1, Jet Tsien1

  • 1Department of Biochemistry, The University of Texas Southwestern Medical Center, Dallas, TX, USA.

Nature Chemistry
|June 26, 2026
PubMed
Summary

Researchers developed a new method to synthesize bridgehead-substituted [2]-ladderanes. These strained hydrocarbons are versatile building blocks for creating complex molecules and functionalized bicyclo[2.2.2]octanes (BCOs).

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