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Related Experiment Video

Updated: Jun 28, 2026

Stereotactic Radiosurgery for Gynecologic Cancer
10:35

Stereotactic Radiosurgery for Gynecologic Cancer

Published on: April 17, 2012

Factors Associated With Preoperative Radiological Tumor Size Underestimation in Clinical T1-2 Breast Cancer Patients.

Jungbin Kim1, Yujin Lee1, Sam-Youl Yoon1

  • 1Department of Surgery, College of Medicine, Sanggye Paik Hospital, Inje University, Seoul, South Korea, inje.ac.kr.

The Breast Journal
|June 27, 2026
PubMed
Summary

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Higher BMI and invasive lobular carcinoma predict underestimation of breast cancer tumor size. This finding highlights the need for advanced imaging and intraoperative margin assessment in these patients.

Area of Science:

  • Oncology
  • Radiology
  • Surgical Pathology

Background:

  • Accurate preoperative tumor size is crucial for surgical margin planning in breast cancer.
  • Radiological underestimation can impact treatment decisions and outcomes.

Purpose of the Study:

  • To identify factors associated with preoperative radiological tumor underestimation in clinical T (cT) Stage 1-2 breast cancer patients.
  • To evaluate the impact of body mass index (BMI) and histological subtype on tumor size discrepancies.

Main Methods:

  • Retrospective review of 365 cT1-2 breast cancer patients' data.
  • Radiological tumor size measured by ultrasonography or MRI; underestimation defined by pathological-to-radiological ratio > 1.2 or discrepancy ≥ 5mm.
  • Analysis of preoperative variables including BMI, cT stage, molecular and histologic subtypes.
Keywords:
body mass indexbreast neoplasmscarcinomahistologylobularradiology

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Stereotactic Radiosurgery for Gynecologic Cancer
10:35

Stereotactic Radiosurgery for Gynecologic Cancer

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Main Results:

  • A BMI ≥ 25 kg/m² and invasive lobular carcinoma (ILC) histology were significantly associated with radiological underestimation.
  • Tumor size discrepancy was greater in patients with BMI ≥ 25 kg/m² and in those with ILC.
  • Bland-Altman analysis indicated radiological underestimation of 4.3mm in ILC cases.

Conclusions:

  • Elevated BMI (≥ 25 kg/m²) and ILC histology are predictive of preoperative radiological tumor underestimation in early-stage breast cancer.
  • These findings suggest the need for supplemental imaging and intraoperative margin assessment in at-risk patients.
  • Improved preoperative assessment can lead to more precise surgical planning and better patient outcomes.