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Related Experiment Videos

Association between maternal serum RANKL and adverse birth outcomes: a prospective cohort study.

Xiaoqiong Wu1, Jiamei Wang2, Aiqi Yin3

  • 1Jiaxing Center for Disease Control and Prevention, Jiaxing, Zhejiang, China.

Annals of Medicine
|June 27, 2026
PubMed
Summary

Maternal serum RANKL levels in mid-pregnancy are linked to a higher risk of small for gestational age (SGA) births. This finding suggests RANKL may help predict adverse birth outcomes.

Keywords:
RANKLadverse birth outcomesbiomarkerspregnancy

Related Experiment Videos

Area of Science:

  • Reproductive Biology
  • Immunology
  • Public Health

Background:

  • Adverse birth outcomes represent a significant global health challenge.
  • The role of RANKL in immune regulation and bone metabolism is known, but its specific connection to adverse birth outcomes requires further investigation.

Purpose of the Study:

  • To investigate the association between maternal serum RANKL levels during the second trimester and various adverse birth outcomes, including preterm birth (PTB), birth defects (BD), small for gestational age (SGA), large for gestational age (LGA), low birth weight (LBW), and macrosomia.

Main Methods:

  • A cross-sectional study was conducted in South China.
  • Maternal serum samples were collected between 13-20 gestational weeks.
  • Serum RANKL levels were quantified, and associations were analyzed using logistic regression and restricted cubic spline models.

Main Results:

  • Elevated maternal serum RANKL levels in mid-pregnancy showed a significant positive association with SGA.
  • Receiver Operating Characteristic (ROC) analysis indicated that serum RANKL possesses discriminatory capability for identifying SGA and LBW.

Conclusions:

  • Mid-pregnancy maternal serum RANKL levels are associated with an increased risk of delivering a small for gestational age (SGA) infant.
  • Serum RANKL may emerge as a valuable biomarker for assessing the risk of adverse birth outcomes.
  • These results offer novel insights into the etiological factors contributing to adverse birth outcomes.