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Amorphous FeBP Magnetic Beads with l-Ascorbic Acid Modification for Efficient Sperm Separation in Forensic Analysis.

Junjie Yan1, Dong Zhao2, Lan Wang3

  • 1Key Laboratory of Anisotropy and Texture of Materials (Ministry of Education), School of Materials Science and Engineering, Northeastern University, Shenyang 110819, China.

Langmuir : the ACS Journal of Surfaces and Colloids
|June 27, 2026
PubMed
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Researchers developed novel core-shell magnetic beads using amorphous magnetic particles and l-ascorbic acid (ASA) for improved sperm cell separation. These beads offer faster magnetic response and higher capture rates, enhancing forensic identification applications.

Area of Science:

  • Materials Science
  • Biotechnology
  • Forensic Science

Background:

  • Magnetic-activated cell sorting (MACS) is promising for forensic identification.
  • Current magnetic beads have slow magnetic responsiveness and issues with residual reagents.
  • Efficient cell separation is crucial for forensic applications.

Purpose of the Study:

  • To develop core-shell magnetic beads with enhanced magnetic responsiveness and biocompatibility.
  • To improve sperm cell separation efficiency for forensic identification.
  • To overcome limitations of existing commercial magnetic beads.

Main Methods:

  • Fabrication of amorphous FeBP core-shell magnetic beads.
  • Surface modification using l-ascorbic acid (ASA).

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  • Characterization using SEM, TEM, XRD, ζ-potential, FTIR, XPS, and VSM.
  • Evaluation of sperm separation using qPCR.

    • Main Results:

    • ASA-modified FeBP beads showed high saturation magnetization (>40% higher than conventional particles).
    • Achieved an 84% sperm cell capture rate, a 25.4% enhancement over commercial beads.
    • Demonstrated a magnetic response speed approximately 3 times faster than commercial beads.
    • Exhibited excellent long-term stability with 97% capture rate after 60 days.

    Conclusions:

    • Core-shell magnetic beads with ASA modification offer superior performance for cell separation.
    • The developed beads provide a faster, more efficient, and stable method for sperm identification.
    • This advancement has significant implications for forensic science and efficient cell separation technologies.