Related Experiment Video
Updated: Jun 28, 2026
Ocular Kinematics Measured by In Vitro Stimulation of the Cranial Nerves in the Turtle
Published on: June 2, 2018
Association between dynamic pupil parameters and corneal sub-basal nerve plexus morphology
Wenyan Zhou1,2, Zhiyu Zhang1, Haozhe Yu1
1Department of Ophthalmology, Peking University First Hospital, Beijing, China.
Purpose:
To evaluate the association between dynamic pupillometry parameters and in vivo confocal microscopy (IVCM)-derived corneal sub-basal nerve morphology in patients with immune-related dry eye disease.
Methods:
A cross-sectional study was conducted on 28 patients with immune-related dry eye disease (DED). Corneal sub-basal nerve morphology, including corneal nerve fiber length density (CNFL), intensity, and tortuosity, was quantified using IVCM. Dynamic pupillary light reflexes, including pupil size diameter and constriction/dilation velocities, were measured via automated pupillometry. Correlation and multivariate regression analysis were employed to determine the independent associations between structural nerve metrics and functional pupillary parameters.
Results:
Significant positive correlations were observed between CNFL and baseline pupil size, recovery pupil size, and total contraction and dilation time. Multivariate regression confirmed that CNFL remained an independent predictor of baseline pupil diameter after adjusting for age and gender.
Conclusion:
Structural rarefaction of the corneal sub-basal nerves is closely mirrored by functional impairments in pupillary dynamics. Dynamic pupillometry may provide complementary functional information associated with corneal nerve alterations in patients with immune-related DED.
