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Updated: Jun 29, 2026

Assessment of Human Natural Killer Cell Events Driven by FcγRIIIa Engagement in the Presence of Therapeutic Antibodies

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CD43: Recent Advances and Emerging Functions.

Mariana Diupotex^1,2, Veronica Rojo-Leon^1,2, Luis Eduardo Chipres-Naranjo^1,3

¹Departamento de Medicina Molecular y Bioprocesos, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, Morelos, México.

Journal of Leukocyte Biology

|June 27, 2026

Summary

This summary is machine-generated.

CD43, a glycoprotein on immune cells, acts as a context-dependent regulator of immune responses. Its varied roles in activation, trafficking, and disease highlight its potential as a therapeutic target.

Keywords:

CD43 cancer immunology host-pathogen interactions immune regulation leukocyte function

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Published on: May 22, 2020

Single-Molecule Localization Microscopy of Membrane Proteins using Single-Antibody Labeling

Single-Molecule Localization Microscopy of Membrane Proteins using Single-Antibody Labeling

Published on: March 20, 2026

Area of Science:

Immunology
Glycobiology
Cell Biology

Background:

CD43 is a mucin-like sialoglycoprotein expressed on hematopoietic cells, particularly leukocytes.
Its expression, structure, and interactions vary by cell type, activation, and differentiation state.
CD43 integrates microenvironmental cues and glycosylation with cell surface organization and signaling.

Purpose of the Study:

To review current knowledge on CD43 regulation, structure, and ligand interactions.
To discuss the multifaceted roles of CD43 in diverse physiological and pathological settings.
To propose CD43 as a dynamic regulator of immune responses and a potential therapeutic target.

Main Methods:

Literature review of studies on CD43 expression, function, and regulation.
Analysis of CD43's involvement in immune activation, leukocyte trafficking, and disease contexts.
Synthesis of information on CD43's structural organization and ligand binding.

Main Results:

CD43 exhibits context-dependent functions, influencing immune activation, regulation, and dysfunction.
It plays roles in leukocyte trafficking, host-pathogen interactions, and cancer immune evasion.
CD43's signaling, glycosylation, and ligand engagement are critical in modulating immune responses.

Conclusions:

CD43 is a dynamic and adaptable regulator of immune responses.
Its diverse roles across different cellular and disease contexts underscore its significance.
CD43 represents a promising therapeutic target for immune-mediated diseases.