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Related Experiment Video

Updated: Jun 29, 2026

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

Published on: January 21, 2020

Oral Health, Periodontitis, and Respiratory Diseases: Biological Pathways.

Raluca P Vacaru¹, Andreea C Didilescu¹, Frank A Scannapieco²

¹Department of Embryology and Microbiology, Faculty of Dentistry, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.

Journal of Periodontal Research

|June 27, 2026

Summary

Poor oral hygiene and periodontitis increase the risk of lung diseases like pneumonia and COPD. Maintaining good oral hygiene and treating gum disease are crucial for preventing and managing respiratory conditions.

Keywords:

oral health periodontal diseases pulmonology respiratory tract infections

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Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

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Published on: January 21, 2020

A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites

A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites

Published on: August 8, 2014

Area of Science:

Oral health
Microbiology
Pulmonology

Background:

The lung microbiome is a distinct ecosystem influenced by oral microaspiration.
The mouth harbors key respiratory pathogens and oral microbes.
Poor oral hygiene and periodontitis increase aspirated bacterial load and inflammation.

Purpose of the Study:

To explore the influence of the oral-lung axis on respiratory diseases.
To understand the mechanisms linking oral health to lung conditions.
To emphasize the importance of integrating oral care into respiratory disease management.

Main Methods:

Review of existing literature on the oral-lung axis.
Analysis of biological pathways involving oral pathogens and lung inflammation.
In vitro studies examining the oral-lung axis mechanisms.

Main Results:

Poor oral hygiene and periodontitis are linked to increased risk and severity of pneumonia, COPD, COVID-19, and asthma.
Periodontitis can exacerbate lung conditions by altering immune function, promoting inflammation, and increasing pathogen virulence.
Inflammation from periodontitis impacts lung microbiome composition and host defense.

Conclusions:

The oral-lung axis plays a significant role in the pathogenesis of major respiratory diseases.
Effective periodontal treatment and oral hygiene are essential components of respiratory disease prevention and management.
Integrating oral health into overall medical care can improve patient outcomes for lung conditions.